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Article
Open AccessS-nitrosothiol homeostasis maintained by ADH5 facilitates STING-dependent host defense against pathogens
Oxidative (or respiratory) burst confers host defense against pathogens by generating reactive species, including reactive nitrogen species (RNS). The microbial infection-induced excessive RNS damages many bio...
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Article
Open AccessMyristic acid as a checkpoint to regulate STING-dependent autophagy and interferon responses by promoting N-myristoylation
Stimulator of interferon gene (STING)-triggered autophagy is crucial for the host to eliminate invading pathogens and serves as a self-limiting mechanism of STING-induced interferon (IFN) responses. Thus, the ...
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Article
Open AccessTOB1 attenuates IRF3-directed antiviral responses by recruiting HDAC8 to specifically suppress IFN-β expression
Interferon regulatory factor 3 (IRF3) is a key transcription factor required for the secretion of type I interferons (IFN-α/β) and initiation of antiviral immune response. However, the negative feedback regula...
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Article
Open AccessTRIM28 SUMOylates and stabilizes NLRP3 to facilitate inflammasome activation
The cellular NLRP3 protein level is crucial for assembly and activation of the NLRP3 inflammasome. Various posttranslational modifications (PTMs), including phosphorylation and ubiquitination, control NLRP3 pr...
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Article
Open AccessUAF1 deubiquitinase complexes facilitate NLRP3 inflammasome activation by promoting NLRP3 expression
NOD-like receptor protein 3 (NLRP3) detects microbial infections or endogenous danger signals and activates the NLRP3 inflammasome, which has important functions in host defense and contributes to the pathogen...
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Article
Redox homeostasis maintained by GPX4 facilitates STING activation
Stimulator-of-interferon genes (STING) is vital for sensing cytosolic DNA and initiating innate immune responses against microbial infection and tumors. Redox homeostasis is the balance of oxidative and reduci...
