123 Result(s)
within
Muhammad Imran Khan
-
Article
Nystatin, Aspirin and Lidocaine Containing Orodispersible Films for Pronounced Drug Delivery: Development and Characterization
Buccal drug delivery systems have emerged as a promising approach for achieving local effects in the oral cavity, providing an alternative to parenteral routes and addressing the stability issues of drugs expe...
-
Article
Revolutionizing Hypertension Management: Cutting-Edge Microneedle Patch Infused with Zinc Oxide Nanoparticles for Advanced Transdermal Drug Delivery
Transdermal drug delivery methods prove markedly superior to oral or hypodermic alternatives. By circumventing first-pass medication metabolism and gastrointestinal breakdown, these methods afford patients inc...
-
Article
Molecular mechanisms of morphine tolerance and dependence; novel insights and future perspectives
Drug addiction is a devastating condition that poses a serious burden on the society. The use of some drugs like morphine for their tremendous analgesic properties is also accompanied with develo** tolerance...
-
Article
Open AccessAnti-pruritic effect of L-carnitine against chloroquine-induced pruritus mediated via nitric oxide pathway
Pruritus, or itching, is a distressing symptom associated with various dermatological and systemic diseases. L-carnitine (βeta hydroxy-γ-tri methyl amino-butyric acid), is a naturally occurring substance, it c...
-
Article
Open AccessEnhanced wheat productivity in saline soil through the combined application of poultry manure and beneficial microbes
Soil salinity is one of the major menaces to food security, particularly in dealing with the food demand of the ever-increasing global population. Production of cereal crops such as wheat is severely affected ...
-
Article
Open AccessDynamics of Malaria Incidence in Khyber Pakhtunkhwa, Pakistan: Unveiling Rapid Growth Patterns and Forecasting Future Trends
Malaria remains a formidable worldwide health challenge, with approximately half of the global population at high risk of catching the infection. This research study aimed to address the pressing public health...
-
Article
Development and Characterization of Glimepiride-Loaded Polymeric Nanoparticles: Formulation Design and Evaluation
This study was aimed to develop polymeric nanoparticles (PNPs) using chitosan (CTN), polyvinyl pyrrolidone (PVP), and Tween 80 for dissolution enhancement of poorly water-soluble antidiabetic drug: glimeperide...
-
Article
A comprehensive review on the applications of ferrite nanoparticles in the diagnosis and treatment of breast cancer
Various conventional treatments including endocrine therapy, radiotherapy, surgery, and chemotherapy have been used for several decades to treat breast cancer; however, these therapies exhibit various life-thr...
-
Living Reference Work Entry In depth
Bainbridge-Ropers Syndrome
Bainbridge-Ropers syndrome (BRPS) is a rare genetic disorder that results from a functional de novo mutation in an additional sex combs-like 3 (ASXL3) gene. The mutation usually occurs in chromosome 18q12 in the
-
Article
Investigation of the Thermomechanical and Tribological Behaviors of a Non-equimolar Hf0.5Nb0.5Ta0.5Ti1.5Zr Refractory High Entropy Alloy
Mechanical, physical, thermodynamic and wear resistance properties of a non-equimolar and complex Hf0.5Nb0.5Ta0.5Ti1.5Zr refractory HEA, were studied. Various thermodynamic parameters like mixing enthalpy (ΔHmix)...
-
Article
Water Waste Monitoring Using Neutrosophic Multivariate T2 Control Chart
In numerous wastewater treatment processes, the parameters of biological oxygen demand (BOD), chemical oxygen demand (COD), and total suspended solids (TSS) assume a pivotal role. Typically, conventional stati...
-
Article
A bacterial consortium and L-tryptophan boosted glyphosate removal, mungbean growth and physiology in contaminated soil
Here, a pot experiment was carried out to assess the effectiveness of co-application of a microbial consortium and L-tryptophan (L-TRP) on bioremediation of glyphosate and growth of mungbean (Vigna radiata L.) in...
-
Article
Open AccessStem cells-derived exosomes alleviate neurodegeneration and Alzheimer’s pathogenesis by ameliorating neuroinflamation, and regulating the associated molecular pathways
Amyloid beta (Aβ) aggregation and tau hyper phosphorylation (p-tau) are key molecular factors in Alzheimer’s disease (AD). The abnormal formation and accumulation of Aβ and p-tau lead to the formation of amylo...
-
Article
In vitro antioxidant and antibacterial activities of ethanolic extracts from the leaves and stems of Oudneya Africana R. growing in the El Oued (Algeria)
This work is a component of the development of the aerial parts (leaves and stems) of Oudneya africana R., of the Brassicaceae family. For that purpose, the total phenolic content (TPC), total flavonoid content (...
-
Article
Polyoxyethylene Lauryl Ether (Brij-35) and Poloxamer 407–Based Non-ionic Surfactant Vesicles for Dissolution Enhancement of Tacrolimus
This study aimed to develop niosomes using polyoxyethylene lauryl ether (Brij-35) and poloxamer 407 surfactants for dissolution enhancement of tacrolimus, a poorly water-soluble drug for improving oral bioavai...
-
Article
Open AccessSynthesis and characterization of Hyaluronic Acid (HA) modified polymeric composite for effective treatment of wound healing by transdermal drug delivery system (TDDS)
The present study aimed to fabricate a novel polymeric spongy composite to enhance skin regeneration composed of Nystatin (antifungal agent) and Silver Nanoparticles (AgNps). Different formulations (F1–F8) wer...
-
Article
Adverse health effects and mechanisms of microplastics on female reproductive system: a descriptive review
Microplastics (MPs), with a diameter of less than 5 mm, include polymers such as polystyrene, polypropylene, and polyethylene. The MPs occur in different morphologies including fragments, beads, fibers, and fi...
-
Article
Open AccessMicroneedle array facilitates hepatic sinusoid construction in a large-scale liver-acinus-chip microsystem
Hepatic sinusoids play a key role in maintaining high activities of liver cells in the hepatic acinus. However, the construction of hepatic sinusoids has always been a challenge for liver chips, especially for...
-
Article
Pterostilbene reduces the progression of atopic dermatitis via modulating inflammatory and oxidative stress biomarkers in mice
Atopic dermatitis (AD) is one of the most prevalent chronic skin inflammatory disorders requiring continuous treatment and care. Pterostilbene (PTN) belongs to stilbene and is a polyphenolic compound of natura...
-
Article
The co-application of bioslurry and compost with inorganic zinc fertilizer improved soil quality, zinc uptake, and growth of maize crop
Integrated nutrient management is one of the most effective techniques to tackle soil fertility concerns and boost crop productivity. Taking this into consideration, a pot experiment was carried out to determi...
