22 Result(s)
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Morgan G. I. Langille
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Article
Open AccessOral microbial signatures associated with age and frailty in Canadian adults
This study aimed to assess the association between the oral microbiome, age, and frailty. Data and saliva samples were obtained from male and female participants aged 35–70 years (n = 1357). Saliva samples wer...
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Article
Open AccessMicrobial hitchhikers harbouring antimicrobial-resistance genes in the riverine plastisphere
The widespread nature of plastic pollution has given rise to wide scientific and social concern regarding the capacity of these materials to serve as vectors for pathogenic bacteria and reservoirs for Antimicr...
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Open AccessCross-study analyses of microbial abundance using generalized common factor methods
By creating networks of biochemical pathways, communities of micro-organisms are able to modulate the properties of their environment and even the metabolic processes within their hosts. Next-generation high-t...
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Article
Open AccessInvestigating the oral microbiome in retrospective and prospective cases of prostate, colon, and breast cancer
The human microbiome has been proposed as a potentially useful biomarker for several cancers. To examine this, we made use of salivary samples from the Atlantic Partnership for Tomorrow’s Health (PATH) project...
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Article
Open AccessExploring the microbiome of oral epithelial dysplasia as a predictor of malignant progression
A growing body of research associates the oral microbiome and oral cancer. Well-characterized clinical samples with outcome data are required to establish relevant associations between the microbiota and disea...
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Article
Open AccessAuthor Correction: Microbiome differential abundance methods produce different results across 38 datasets
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Article
Open AccessMicrobiome differential abundance methods produce different results across 38 datasets
Identifying differentially abundant microbes is a common goal of microbiome studies. Multiple methods are used interchangeably for this purpose in the literature. Yet, there are few large-scale studies systema...
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Article
Open AccessCorrection to: A multi-OMIC characterisation of biodegradation and microbial community succession within the PET plastisphere
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Article
Open AccessA multi-OMIC characterisation of biodegradation and microbial community succession within the PET plastisphere
Plastics now pollute marine environments across the globe. On entering these environments, plastics are rapidly colonised by a diverse community of microorganisms termed the plastisphere. Members of the plasti...
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Article
Open AccessIdentifying biases and their potential solutions in human microbiome studies
Advances in DNA sequencing technology have vastly improved the ability of researchers to explore the microbial inhabitants of the human body. Unfortunately, while these studies have uncovered the importance of...
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Article
Open AccessRe-evaluating the relationship between missing heritability and the microbiome
Human genome-wide association studies (GWASs) have recurrently estimated lower heritability estimates than familial studies. Many explanations have been suggested to explain these lower estimates, including th...
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Article
PICRUSt2 for prediction of metagenome functions
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Article
Author Correction: Reproducible, interactive, scalable and extensible microbiome data science using QIIME 2
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
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Article
Reproducible, interactive, scalable and extensible microbiome data science using QIIME 2
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Article
Open AccessEnhancement of the gut barrier integrity by a microbial metabolite through the Nrf2 pathway
The importance of gut microbiota in human health and pathophysiology is undisputable. Despite the abundance of metagenomics data, the functional dynamics of gut microbiota in human health and disease remain el...
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Article
Open AccessMulti-omics differentially classify disease state and treatment outcome in pediatric Crohn’s disease
Crohn’s disease (CD) has an unclear etiology, but there is growing evidence of a direct link with a dysbiotic microbiome. Many gut microbes have previously been associated with CD, but these have mainly been c...
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Article
Open Access“Available upon request”: not good enough for microbiome data!
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Protocol
Processing a 16S rRNA Sequencing Dataset with the Microbiome Helper Workflow
Sequencing microbiome samples has recently become a fast and cost-effective method to taxonomically profile communities. The growing interest in analyzing microbial sequencing data has attracted many new resea...
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Protocol
Predicting the Functional Potential of the Microbiome from Marker Genes Using PICRUSt
Marker-gene sequencing is a cost-effective method of taxonomically profiling microbial communities. Unlike metagenomic approaches, marker-gene sequencing does not provide direct information about the functiona...
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Article
The coupling of taxonomy and function in microbiomes
Microbiologists are transitioning from the study and characterization of individual strains or species to the profiling of whole microbiomes and microbial ecology. Equipped with high-throughput methods for stu...
