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Article
Systematic evaluation of pain in neonates: effect on the number of intravenous analgesics prescribed
To document the effect of systematic evaluation of pain in neonates on prescription of intravenous analgesics in a level-III neonatal intensive care unit (NICU) as a marker of increased awareness of treating a...
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Article
Postoperative pain in the neonate: age-related differences in morphine requirements and metabolism
To investigate age-related differences in morphine requirements and metabolism in full-term neonates.
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Article
Sedation and analgesia in the PICU: many questions remain
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Article
Withdrawal symptoms in children after long-term administration of sedatives and/or analgesics: a literature review. “Assessment remains troublesome”
Prolonged administration of benzodiazepines and/or opioids to children in a pediatric intensive care unit (PICU) may induce physiological dependence and withdrawal symptoms.
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Article
Open AccessImpact of a child with congenital anomalies on parents (ICCAP) questionnaire; a psychometric analysis
The objective of this study was to validate the Impact of a Child with Congenital Anomalies on Parents (ICCAP) questionnaire. ICCAP was newly designed to assess the impact of giving birth to a child with sever...
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Article
Open AccessConstruction of the Sophia Observation withdrawal Symptoms-scale (SOS) for critically ill children
To construct a reliable and clinically practical instrument for monitoring opioids and benzodiazepine withdrawal symptoms in pediatric ICU patients.
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Article
Morphine Glucuronidation in Preterm Neonates, Infants and Children Younger than 3 Years
A considerable amount of drug use in children is still unlicensed or off-label. In order to derive rational dosing schemes, the influence of aging on glucuronidation capacity in newborns, including preterms, i...
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Article
Open AccessEndpoints in pediatric pain studies
Assessing pain intensity in (preverbal) children is more difficult than in adults. Tools to measure pain are being used as primary endpoints [e.g., pain intensity, time to first (rescue) analgesia, total analg...
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Article
Open AccessReal-time registration of adverse events in Dutch hospitalized children in general pediatric units: first experiences
The objectives of this study are to describe the number and nature of adverse events occurring in general pediatric practice, to describe factors contributing to the occurrence of these adverse events, and to ...
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Article
Open AccessScreening pediatric delirium with an adapted version of the Sophia Observation withdrawal Symptoms scale (SOS)
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Article
Skin conductance peaks could result from changes in vital parameters unrelated to pain
Pain is usually assessed by the interpretation of behavior, which can be subjective. Therefore, there is an ongoing search for more objective methods. Performance of skin conductance measurement as a pain asse...
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Article
Optimal sedation in pediatric intensive care patients: a systematic review
Sedatives administered to critically ill children should be titrated to effect, because both under- and oversedation may have negative effects. We conducted a systematic review to examine reported incidences o...
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Article
Functional MRI pain studies in children? Yes, we (s)can!
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Article
Evidence-Based Morphine Dosing for Postoperative Neonates and Infants
From a previously validated paediatric population pharmacokinetic model, it was derived that non-linear morphine maintenance doses of 5 μg/kg1.5/h, with a 50 % dose reduction in neonates with a postnatal age (PNA...
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Article
Paediatric critical incident analysis: lessons learnt on analysis, recommendations and implementation
The objectives of this study were to identify causal and contributing factors of serious patient safety incidents in a paediatric university hospital, to report on ensuing recommendations and to assess the ext...
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Article
Open AccessMedication use during end-of-life care in a palliative care centre
Background In end-of-life care, symptoms of discomfort are mainly managed by drug therapy, the guidelines for which are mainly based on expert opinions. A few papers have inventoried drug...
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Article
Open AccessPain in Intellectually Disabled Children: Towards Evidence-Based Pharmacotherapy?
This critical opinion article deals with the challenges of finding the most effective pharmacotherapeutic options for the management of pain in intellectually disabled children and provides recommendations for...
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Article
Open AccessLimited effects of intravenous paracetamol on patent ductus arteriosus in very low birth weight infants with contraindications for ibuprofen or after ibuprofen failure
Finding the optimal pharmacological treatment of a patent ductus arteriosus (PDA) in preterm neonates remains challenging. There is a growing interest in paracetamol as a new drug for PDA closure. In this pros...
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Article
Open AccessClinical recommendations for pain, sedation, withdrawal and delirium assessment in critically ill infants and children: an ESPNIC position statement for healthcare professionals
This position statement provides clinical recommendations for the assessment of pain, level of sedation, iatrogenic withdrawal syndrome and delirium in critically ill infants and children. Admission to a neona...
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Article
Infant Mental Health in het ziekenhuis
Een gehechtheidsrelatie tussen ouders en hun kind begint tijdens de zwangerschap en wordt verder gevormd in contact met het kind. In dit artikel wordt beschreven wat (aanstaande) ouders bij belaste zwangerscha...
