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Open AccessIntermittent intravenous paracetamol versus continuous morphine in infants undergoing cardiothoracic surgery: a multi-center randomized controlled trial
To determine whether intermittent intravenous (IV) paracetamol as primary analgesic would significantly reduce morphine consumption in children aged 0–3 years after cardiac surgery with cardiopulmonary bypass.
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Article
Open AccessValidation of the SOS-PD scale for assessment of pediatric delirium: a multicenter study
Reports of increasing incidence rates of delirium in critically ill children are reason for concern. We evaluated the measurement properties of the pediatric delirium component (PD-scale) of the Sophia Observa...
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Article
Open AccessClinical recommendations for pain, sedation, withdrawal and delirium assessment in critically ill infants and children: an ESPNIC position statement for healthcare professionals
This position statement provides clinical recommendations for the assessment of pain, level of sedation, iatrogenic withdrawal syndrome and delirium in critically ill infants and children. Admission to a neona...
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Optimal sedation in pediatric intensive care patients: a systematic review
Sedatives administered to critically ill children should be titrated to effect, because both under- and oversedation may have negative effects. We conducted a systematic review to examine reported incidences o...
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Open AccessScreening pediatric delirium with an adapted version of the Sophia Observation withdrawal Symptoms scale (SOS)
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Open AccessConstruction of the Sophia Observation withdrawal Symptoms-scale (SOS) for critically ill children
To construct a reliable and clinically practical instrument for monitoring opioids and benzodiazepine withdrawal symptoms in pediatric ICU patients.
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Article
Withdrawal symptoms in children after long-term administration of sedatives and/or analgesics: a literature review. “Assessment remains troublesome”
Prolonged administration of benzodiazepines and/or opioids to children in a pediatric intensive care unit (PICU) may induce physiological dependence and withdrawal symptoms.
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Sedation and analgesia in the PICU: many questions remain
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Postoperative pain in the neonate: age-related differences in morphine requirements and metabolism
To investigate age-related differences in morphine requirements and metabolism in full-term neonates.