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  1. No Access

    Article

    Nondestructive, base-resolution sequencing of 5-hydroxymethylcytosine using a DNA deaminase

    A bisulfite-free sequencing method yields high-confidence 5hmC profiles in low-input samples.

    Emily K Schutsky, Jamie E DeNizio, Peng Hu, Monica Yun Liu… in Nature Biotechnology (2018)

  2. No Access

    Article

    Mutations along a TET2 active site scaffold stall oxidation at 5-hydroxymethylcytosine

    Saturation mutagenesis, molecular modeling and biochemical analysis revealed that active site interactions involving Thr1372 of TET2 are responsible for controlling its proficiency for stepwise oxidation of 5-...

    Monica Yun Liu, Hedieh Torabifard, Daniel J Crawford… in Nature Chemical Biology (2017)