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Article
A surgical orthotopic approach for studying the invasive progression of human bladder cancer
The invasion of bladder cancer into the sub-urothelial muscle and vasculature are key determinants leading to lethal metastatic progression. However, the molecular basis is poorly understood, partly because of...
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Article
Open AccessEvaluation of the Antitumor Activity of Dacomitinib in Models of Human Bladder Cancer
Members of the human epidermal growth factor receptor (HER) family play a significant role in bladder cancer progression and may underlie the development of chemotherapy resistance. Dacomitinib is an irreversi...
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Article
Extravesical cryosurgical approach for VX2 bladder tumor in rabbits
This study characterized the VX2 bladder cancer model in rabbits and tested the feasibility of treating bladder cancer by extravesical cryosurgery. After the growth characteristics of the VX2 bladder tumor mo...
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Article
MMAC1/PTEN inhibits cell growth and induces chemosensitivity to doxorubicin in human bladder cancer cells
The development and progression of bladder cancer is associated with multiple alterations in the genome, including loss of chromosome 10. Recently, MMAC1/PTEN, a phosphatidylinositol phosphatase, has been mapped ...
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Chapter
Urothelial Differentiation and Bladder Cancer
Cancer is the endpoint of a multi-step process of carcinogenesis.1–5 This process involves multiple genetic and epigenetic alterations and cellular selections.2–4,6 These changes result in cell populations with u...
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Article
The intraperitoneal delivery of radiolabeled monoclonal antibodies: studies on the regional delivery advantage
The i.p. delivery of murine monoclonal antibody was compared with i.v. delivery in normal mice and rats, in normal nude mice and in those with i.p. human ovarian carcinoma xenografts. In normal rats, all class...
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Article
High-dose, unlabeled, nonspecific antibody pretreatment: influence on specific antibody localization to human melanoma xenografts
Nonspecific uptake of radiolabeled monoclonal antibodies in normal tissues is a significant problem for tumor imaging. A potential means of decreasing nonspecific antibody binding is to “blockade” nonspecific ...
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Article
CML characterization of a product of a second class I locus in the rat MHC
In the rat, genes that control the expression of target antigens detected by cell-mediated lympholysis (CML) are present in the major histocompatibility complex (MHC). The relationship of these loci, CT and Ag-L,...
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Article
Gene order in the major histocompatibility complex of the rat
The loci in the major histocompatibility complex (MHC) of the rat which code for class I and class II antigens—RT1.A and RT1.B, respectively — have previously been separated by laboratory-derived recombinants and...