15 Result(s)
within
Monica Hernandez Alava
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Article
Open AccessThe trajectory of a range of commonly captured symptoms with standard care in people with kidney failure receiving haemodialysis: consideration for clinical trial design
Despite the recognized high symptom prevalence in haemodialysis population, how these symptoms change over time and its implications for clinical practice and research is poorly understood.
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Article
Open AccessEnabling QALY estimation in mental health trials and care settings: map** from the PHQ-9 and GAD-7 to the ReQoL-UI or EQ-5D-5L using mixture models
Patient-reported outcome measures (PROMs) are commonly collected in trials and some care settings, but preference-based PROMs required for economic evaluation are often missing. For these situations, map** m...
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Article
Open AccessCatalogues of EQ-5D-3L Health-Related Quality of Life Scores for 199 Chronic Conditions and Health Risks for Use in the UK and the USA
Health-related quality of life (HRQoL) measures are essential in economic evaluation, but sometimes primary sources are unavailable, and information from secondary sources is required. Existing HRQoL UK/US cat...
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Article
Open AccessCost Effectiveness of Difelikefalin Compared to Standard Care for Treating Chronic Kidney Disease Associated Pruritus (CKD-aP) in People with Kidney Failure Receiving Haemodialysis
Chronic kidney disease-associated pruritus (CKD-aP) is associated with an increased risk of depression, poor sleep and reduced health-related quality of life. Two phase III studies (KALM-1 and KALM-2) of difel...
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Article
Open AccessEstimating the Relationship Between EQ-5D-5L and EQ-5D-3L: Results from a UK Population Study
The aim of this study was to estimate the relationship between EQ-5D-3L and EQ-5D-5L, in both directions, using a single model.
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Article
Open AccessCorrection to: Map** the EORTC QLQ-C30 to EQ-5D-3L in patients with breast cancer
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Open AccessMap** the EORTC QLQ-C30 to EQ-5D-3L in patients with breast cancer
The types of outcomes measured collected in clinical studies and those required for cost-effectiveness analysis often differ. Decision makers routinely use quality adjusted life years (QALYs) to compare the be...
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Article
Open AccessMap** EQ-5D-3L from the Knee Injury and Osteoarthritis Outcome Score (KOOS)
To develop a map** model to estimate EQ-5D-3L from the Knee Injury and Osteoarthritis Outcome Score (KOOS).
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Article
The Impact of Moving from EQ-5D-3L to -5L in NICE Technology Appraisals
The EuroQol-5 Dimension (EQ-5D) instrument is the National Institute for Health and Care Excellence (NICE)’s preferred measure of health-related quality of life (QoL) in adults. The three-level (3L) value set ...
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Article
Open AccessFamily lifestyle dynamics and childhood obesity: evidence from the millennium cohort study
The prevalence of childhood obesity has been increasing but the causes are not fully understood. Recent public health interventions and guidance aiming to reduce childhood obesity have focused on the whole fam...
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Article
Predicting Productivity Losses from Health-Related Quality of Life Using Patient Data
This paper estimates productivity loss using the health of the patient in order to allow indirect estimation of these costs for inclusion in economic evaluation.
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Article
Open AccessChildren’s Development and Parental Input: Evidence From the UK Millennium Cohort Study
In this study, we use the UK Millennium Cohort Study to estimate a dynamic factor model of child development. Our model follows the children from birth until 7 years of age and allows for both cognitive and no...
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Article
Estimating informal care inputs associated with EQ-5D for use in economic evaluation
This paper estimates informal care need using the health of the patient. The results can be used to predict changes in informal care associated with changes in the health of the patient measured using EQ-5D.
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Article
Open AccessModelling the relationship between the WOMAC osteoarthritis index and EQ-5D
Economic evaluation typically is conducted using health state utilities to estimate treatment benefits. However, such outcomes are often missing from studies of clinical effectiveness. This study aims to bridg...
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Article
Good Practice Guidelines for the use of Statistical Regression Models in Economic Evaluations
Decision-analytic models (DAMs) used to evaluate the cost effectiveness of interventions are pivotal sources of evidence used in economic evaluations. Parameter estimates used in the DAMs are often based on th...
