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Article
Open AccessHeterogeneous associations between interleukin-6 receptor variants and phenotypes across ancestries and implications for therapy
The Phenome-Wide Association Study (PheWAS) is increasingly used to broadly screen for potential treatment effects, e.g., IL6R variant as a proxy for IL6R antagonists. This approach offers an opportunity to addre...
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Article
Open AccessInternational comparisons of laboratory values from the 4CE collaborative to predict COVID-19 mortality
Given the growing number of prediction algorithms developed to predict COVID-19 mortality, we evaluated the transportability of a mortality prediction algorithm using a multi-national network of healthcare sys...
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Article
Open AccessClinical knowledge extraction via sparse embedding regression (KESER) with multi-center large scale electronic health record data
The increasing availability of electronic health record (EHR) systems has created enormous potential for translational research. However, it is difficult to know all the relevant codes related to a phenotype d...
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Article
Joint Models for Time-to-Event Data and Longitudinal Biomarkers of High Dimension
Joint models for longitudinal biomarkers and time-to-event data are widely used in longitudinal studies. Many joint modeling approaches have been proposed to handle different types of longitudinal biomarkers a...
