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Article
The State of Synthetic Cannabinoid Medications for the Treatment of Pain
Synthetic cannabinoids are compounds made in the laboratory to structurally and functionally mimic phytocannabinoids from the Cannabis sativa L. plant, including delta-9-tetrahydrocannabinol (THC). Synthetic cann...
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Article
HIF-1α and MIF enhance neutrophil-driven type 3 immunity and chondrogenesis in a murine spondyloarthritis model
The hallmarks of spondyloarthritis (SpA) are type 3 immunity-driven inflammation and new bone formation (NBF). Macrophage migration inhibitory factor (MIF) was found to be a key driver of the pathogenesis of S...
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Article
Intervertebral disc degeneration and osteoarthritis: a common molecular disease spectrum
Intervertebral disc degeneration (IDD) and osteoarthritis (OA) affecting the facet joint of the spine are biomechanically interdependent, typically occur in tandem, and have considerable epidemiological and pa...
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Article
Understanding synovial cell diversity in post-traumatic OA
Research related to the role of the synovium and its cell constituents during the pathogenies of osteoarthritis (OA) has taken a back seat to that of the cartilage and chondrocytes. The influence of synoviocyt...
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Article
Open AccessEphB4 and ephrinB2 act in opposition in the head and neck tumor microenvironment
Differential outcomes of EphB4-ephrinB2 signaling offers formidable challenge for the development of cancer therapeutics. Here, we interrogate the effects of targeting EphB4 and ephrinB2 in head and neck squam...
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Article
Open AccessSynovial mesenchymal progenitor derived aggrecan regulates cartilage homeostasis and endogenous repair capacity
Aggrecan is a critical component of the extracellular matrix of all cartilages. One of the early hallmarks of osteoarthritis (OA) is the loss of aggrecan from articular cartilage followed by degeneration of th...
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Article
The non-coding RNA interactome in joint health and disease
Non-coding RNAs have distinct regulatory roles in the pathogenesis of joint diseases including osteoarthritis (OA) and rheumatoid arthritis (RA). As the amount of high-throughput profiling studies and mechanis...
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Protocol
MicroRNA In Situ Hybridization in Paraffin-Embedded Human Articular Cartilage and Mouse Knee Joints
MicroRNA (miRNA) in situ hybridization (ISH) is a highly sensitive method that allows for the detection of expression and distribution of miRNAs in fixed paraffin-embedded tissues. MiRNA ISH requires time-cons...
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Article
Ephrins and Eph Receptor Signaling in Tissue Repair and Fibrosis
Fibrosis is a pathological feature of many human diseases that affect multiple organs. The development of anti-fibrotic therapies has been a difficult endeavor due to the complexity of signaling pathways assoc...
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Article
Endoglin haploinsufficiency is associated with differential regulation of extracellular matrix production during skin fibrosis and cartilage repair in mice
Transforming growth factor (TGF)-β is a multifunctional growth factor with potent pro-fibrotic effects. Endoglin is a TGF-β co-receptor that strongly regulates TGF-β signaling in a variety of cell types. Altho...
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Article
Correction: Corrigendum: ADAM10-mediated ephrin-B2 shedding promotes myofibroblast activation and organ fibrosis
Nat. Med.; doi:10.1038/nm.4419; corrected online 20 November 2017 In the version of this article initially published online, the positions of the colored boxes in the key of Figure 5f were inverted. The treatm...
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Article
ADAM10-mediated ephrin-B2 shedding promotes myofibroblast activation and organ fibrosis
TGF-β induces expression of ADAM10, which results in greater shedding of ephrin-B2. This shedding promotes the chemotaxis and activation of myofibroblasts and thus the progression of organ fibrosis.
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Article
Open AccessHigh-fat diet-induced acceleration of osteoarthritis is associated with a distinct and sustained plasma metabolite signature
Metabolic changes induced by high fat diet (HFD) that contribute to osteoarthritis (OA) are poorly understood. We investigated longitudinal changes to metabolites and their contribution to OA pathogenesis in r...
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Article
Erratum: Autophagy: controlling cell fate in rheumatic diseases
Nature Reviews Rheumatology 12, 517–531 (2016) In the above article, the sentence “The ubiquitin-like modifier-activating enzyme ATG7 ubiquitylates autophagy protein 5 (ATG5) so that it can form a functional c...
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Chapter
Antiviral Agents Towards Chikungunya Virus: Structures, Syntheses, and Isolation from Natural Sources
Emerging variants of known RNA viruses present an increasing threat to mankind worldwide through their enlarging impact on morbidity and mortality. One of them is the chikungunya disease, which becomes a major...
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Article
Open AccessNa@SiO2-Mediated Addition of Organohalides to Carbonyl Compounds for the Formation of Alcohols and Epoxides
Alcohols and epoxides were generated by the addition of organohalides to carbonyl compounds in the presence of sodium metal impregnated with silica gel (Na@SiO2) in THF at 25 °C through a radical pathway. Under t...
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Article
Autophagy: controlling cell fate in rheumatic diseases
Autophagy is positively regulated by AMPK, ULK1 and beclin-1 complexes, and negatively regulated by AKT activation, mTORC1 and mTORC2 complexes
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Article
Open AccessThe unfolded protein response genes in human osteoarthritic chondrocytes: PERK emerges as a potential therapeutic target
The unfolded protein response (UPR) is activated following an endoplasmic reticulum (ER) stress. The aim of this study was to investigate the global expression of UPR genes in human OA chondrocytes in induced ...
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Article
Open AccessEpithelium-specific Ets transcription factor-1 acts as a negative regulator of cyclooxygenase-2 in human rheumatoid arthritis synovial fibroblasts
Rheumatoid arthritis (RA) is characterized by excessive synovial inflammation. Cyclooxygenase-2 (COX-2) is an enzyme that catalyzes the conversion of arachidonic acid (AA) into prostaglandins. Epithelium-speci...
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Article
Open AccessCartilage-specific deletion of ephrin-B2 in mice results in early developmental defects and an osteoarthritis-like phenotype during aging in vivo
Ephrins and their related receptors have been implicated in some developmental events. We have demonstrated that ephrin-B2 (EFNB2) could play a role in knee joint pathology associated with osteoarthritis (OA)....
