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Combating Oxidative/Nitrosative Stress with Electrophilic Counterattack Strategies

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  1. Article

    Open Access

    Elevated glucose and oligomeric β-amyloid disrupt synapses via a common pathway of aberrant protein S-nitrosylation

    Metabolic syndrome (MetS) and Type 2 diabetes mellitus (T2DM) increase risk for Alzheimer’s disease (AD). The molecular mechanism for this association remains poorly defined. Here we report in human and rodent...

    Mohd Waseem Akhtar, Sara Sanz-Blasco, Nima Dolatabadi… in Nature Communications (2016)

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  2. Article

    Open Access

    NitroSynapsin therapy for a mouse MEF2C haploinsufficiency model of human autism

    Transcription factor MEF2C regulates multiple genes linked to autism spectrum disorder (ASD), and human MEF2C haploinsufficiency results in ASD, intellectual disability, and epilepsy. However, molecular mechan...

    Shichun Tu, Mohd Waseem Akhtar, Rosa Maria Escorihuela… in Nature Communications (2017)

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