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Article
Open AccessNitroSynapsin therapy for a mouse MEF2C haploinsufficiency model of human autism
Transcription factor MEF2C regulates multiple genes linked to autism spectrum disorder (ASD), and human MEF2C haploinsufficiency results in ASD, intellectual disability, and epilepsy. However, molecular mechan...
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Article
Open AccessElevated glucose and oligomeric β-amyloid disrupt synapses via a common pathway of aberrant protein S-nitrosylation
Metabolic syndrome (MetS) and Type 2 diabetes mellitus (T2DM) increase risk for Alzheimer’s disease (AD). The molecular mechanism for this association remains poorly defined. Here we report in human and rodent...
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Chapter
Combating Oxidative/Nitrosative Stress with Electrophilic Counterattack Strategies
Redox stress is thought to contribute to neurodegenerative disorders, including Alzheimer’s and Parkinson’s diseases. Cysteine-based redox regulation, via glutathione- and thioredoxin-mediated pathways, repres...