7 Result(s)
within
Mohammad M. Karimi
Science, Humanities and Social Sciences, multidisciplinary
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Article
Open AccessCohesin couples transcriptional bursting probabilities of inducible enhancers and promoters
Innate immune responses rely on inducible gene expression programmes which, in contrast to steady-state transcription, are highly dependent on cohesin. Here we address transcriptional parameters underlying thi...
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Article
Open AccessThe order and logic of CD4 versus CD8 lineage choice and differentiation in mouse thymus
CD4 and CD8 mark helper and cytotoxic T cell lineages, respectively, and serve as coreceptors for MHC-restricted TCR recognition. How coreceptor expression is matched with TCR specificity is central to underst...
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Article
Open AccessSurveillance of cohesin-supported chromosome structure controls meiotic progression
Chromosome movements and programmed DNA double-strand breaks (DSBs) promote homologue pairing and initiate recombination at meiosis onset. Meiotic progression involves checkpoint-controlled termination of thes...
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Article
Open AccessLTR retrotransposons transcribed in oocytes drive species-specific and heritable changes in DNA methylation
De novo DNA methylation (DNAme) during mouse oogenesis occurs within transcribed regions enriched for H3K36me3. As many oocyte transcripts originate in long terminal repeats (LTRs), which are heterogeneous eve...
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Article
On the role of H3.3 in retroviral silencing
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Article
An ultra-low-input native ChIP-seq protocol for genome-wide profiling of rare cell populations
Combined chromatin immunoprecipitation and next-generation sequencing (ChIP-seq) has enabled genome-wide epigenetic profiling of numerous cell lines and tissue types. A major limitation of ChIP-seq, however, i...
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Article
Vitamin C induces Tet-dependent DNA demethylation and a blastocyst-like state in ES cells
Vitamin C is a direct regulator of Tet enzyme activity and DNA methylation fidelity in mouse ES cells; addition of vitamin C promotes Tet activity, increases 5-hydroxymethlycytosine (5hmC) and DNA demethylatio...
