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Article
Author Correction: Maternal vitamin C regulates reprogramming of DNA methylation and germline development
An Amendment to this paper has been published and can be accessed via a link at the top of the paper.
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Article
Maternal vitamin C regulates reprogramming of DNA methylation and germline development
Development is often assumed to be hardwired in the genome, but several lines of evidence indicate that it is susceptible to environmental modulation with potential long-term consequences, including in mammals1,2
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Article
Open AccessVitamin C induces specific demethylation of H3K9me2 in mouse embryonic stem cells via Kdm3a/b
Histone methylation patterns regulate gene expression and are highly dynamic during development. The erasure of histone methylation is carried out by histone demethylase enzymes. We had previously shown that v...
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Article
Vitamin C induces Tet-dependent DNA demethylation and a blastocyst-like state in ES cells
Vitamin C is a direct regulator of Tet enzyme activity and DNA methylation fidelity in mouse ES cells; addition of vitamin C promotes Tet activity, increases 5-hydroxymethlycytosine (5hmC) and DNA demethylatio...
