-
Article
Open AccessMultisensory gamma stimulation promotes glymphatic clearance of amyloid
The glymphatic movement of fluid through the brain removes metabolic waste1–4. Noninvasive 40 Hz stimulation promotes 40 Hz neural activity in multiple brain regions and attenuates pathology in mouse models of Al...
-
Article
Author Correction: Single-nucleus multiregion transcriptomic analysis of brain vasculature in Alzheimer’s disease
-
Article
Single-nucleus multiregion transcriptomic analysis of brain vasculature in Alzheimer’s disease
Cerebrovascular dysregulation is a hallmark of Alzheimer’s disease (AD), but the changes that occur in specific cell types have not been fully characterized. Here, we profile single-nucleus transcriptomes in t...
-
Article
Insights into Alzheimer’s disease from single-cell genomic approaches
Alzheimer’s disease (AD) is an age-related disease pathologically defined by the deposition of amyloid plaques and neurofibrillary tangles in the brain parenchyma. Single-cell profiling has shown that Alzheime...
-
Article
The microbiota regulate neuronal function and fear extinction learning
Multicellular organisms have co-evolved with complex consortia of viruses, bacteria, fungi and parasites, collectively referred to as the microbiota1. In mammals, changes in the composition of the microbiota can ...
-
Article
A genetically encoded near-infrared fluorescent calcium ion indicator
We report an intensiometric, near-infrared fluorescent, genetically encoded calcium ion (Ca2+) indicator (GECI) with excitation and emission maxima at 678 and 704 nm, respectively. This GECI, designated NIR-GECO1...
-
Article
Open AccessDynamic changes in neural circuitry during adolescence are associated with persistent attenuation of fear memories
Fear can be highly adaptive in promoting survival, yet it can also be detrimental when it persists long after a threat has passed. Flexibility of the fear response may be most advantageous during adolescence w...
