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Article
Open AccessUltrasonic barrier-through imaging by Fabry-Perot resonance-tailoring panel
Imaging technologies that provide detailed information on intricate shapes and states of an object play critical roles in nanoscale dynamics, bio-organ and cell studies, medical diagnostics, and underwater det...
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Article
Open AccessPrognostic utility of body composition parameters based on computed tomography analysis of advanced non-small cell lung cancer treated with immune checkpoint inhibitors
The purpose of this study was to evaluate the prognostic impact of body composition parameters based on computed tomography (CT) in patients with non-small cell lung cancer (NSCLC) who received ICI treatment.
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Article
Monalizumab efficacy correlates with HLA-E surface expression and NK cell activity in head and neck squamous carcinoma cell lines
NKG2A, an inhibitory receptor expressed on NK cells and T cells, leads to immune evasion by binding to HLA-E expressed on cancer cells. Here, we investigated the relationship between HLA-E surface expression o...
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Article
Open AccessLongitudinal multi-omics study of palbociclib resistance in HR-positive/HER2-negative metastatic breast cancer
Cyclin-dependent kinase 4/6 inhibitor (CDK4/6) therapy plus endocrine therapy (ET) is an effective treatment for patients with hormone receptor-positive/human epidermal receptor 2-negative metastatic breast ca...
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Article
Predictive role of galectin-3 for immune checkpoint blockades (ICBs) in advanced or metastatic non-small cell lung cancer: a potential new marker for ICB resistance
We aimed to assess the predictive value of galectin-3 (Gal-3) in patients with non-small cell lung cancer (NSCLC) treated with immune checkpoint blockades (ICBs) therapy using both enzyme-linked immunosorbent ...
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Chapter and Conference Paper
Utilizing Machine Learning to Predict Breast Cancer: One Step Closer to Bridging the Gap Between the Nature Versus Nurture Debate
with breast cancer, scientists have been trying to find the most effective solutions and treatments. Moreover, studies on genes through machine learning were conducted. By identifying the factor that influence...
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Chapter
Patient Autonomy and User Autonomy in the Ecology of Care
Patient autonomy is the foundational moral principle of healthcare. In this chapter, I review how autonomy has been conceptualized in the medical field and compare that with understandings of autonomy discusse...
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Article
Prognostic role of tumor subtype and germline BRCA mutation in advanced breast cancer patients treated with palbociclib plus endocrine therapy
Palbociclib is a cyclin-dependent kinase 4 and 6 inhibitor which shows promising effect in hormone receptor-positive breast cancer. The purpose of this study is to evaluate the real-world efficacy and toxicity...
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Article
Open AccessHigh tumor hexokinase-2 expression promotes a pro-tumorigenic immune microenvironment by modulating CD8+/regulatory T-cell infiltration
Relationship between cancer cell glycolysis and the landscape of tumor immune microenvironment in human cancers was investigated.
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Article
Open AccessLimited efficacy of tocilizumab in adult patients with secondary hemophagocytic lymphohistiocytosis: a retrospective cohort study
Interleukin (IL)-6 is one of the key cytokines in the pathogenesis of secondary hemophagocytic lymphohistiocytosis (sHLH); however, the efficacy and safety of tocilizumab (TCZ), a monoclonal IL-6 receptor anti...
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Article
Open AccessDNA methylome and single-cell transcriptome analyses reveal CDA as a potential druggable target for ALK inhibitor–resistant lung cancer therapy
Acquired resistance to inhibitors of anaplastic lymphoma kinase (ALK) is a major clinical challenge for ALK fusion-positive non-small-cell lung cancer (NSCLC). In the absence of secondary ALK mutations, epigeneti...
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Article
Open AccessBlockade of CD47 enhances the antitumor effect of macrophages in renal cell carcinoma through trogocytosis
Immune checkpoint inhibitors and vascular endothelial growth factor receptor tyrosine kinase inhibitors (VEGFR TKIs) are mainstream treatments for renal cell carcinoma (RCC). Both T cells and macrophages infil...
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Article
Open AccessL-shape triple defects in a phononic crystal for broadband piezoelectric energy harvesting
This study proposes a phononic crystal (PnC) with triple defects in an L-shape arrangement for broadband piezoelectric energy harvesting (PEH). The incorporation of defects in PnCs has attracted significant at...
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Article
Open AccessHighly tunable low frequency metamaterial cavity for vibration localization
Metamaterial cavity has gathered much attention recently due to its capability of localizing vibration energy. Despite the active research, however, there are still big technical challenges not solved yet. Esp...
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Article
Open AccessPiezoelectric energy harvesting using mechanical metamaterials and phononic crystals
Mechanical metamaterials and phononic crystals enable localizing, focusing, and guiding of elastic or acoustic waves in various ways. Here, we describe the physical mechanisms underpinning wave manipulation an...
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Article
Open AccessExtremely low frequency wave localization via elastic foundation induced metamaterial with a spiral cavity
We proposed a metamaterial which exhibits elastic wave localization at extremely low frequencies. First, we opened an extremely low bandgap via elastic foundations. Subsequently, we investigated wave localizat...
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Chapter and Conference Paper
Designing for Distance Nursing: Reconnecting Nursing Students with Senior Home Residents During COVID-19
During the COVID-19 pandemic, nursing students were compelled to receive remote geriatric education due to social distancing mandates. However, for older adults who lack technology literacy, there has been lim...
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Chapter and Conference Paper
Technology, Autonomy, and Participation: Designing Community Games and Services to Enhance Older Adults’ Technology Literacy
Broadly speaking, adults aged 65 and older are not as technologically literate as younger populations. They do not seek digital services, such as online banking and ridesharing services, as readily as younger ...
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Article
Open AccessDouble defects-induced elastic wave coupling and energy localization in a phononic crystal
This study aims to investigate elastic wave localization that leverages defect band splitting in a phononic crystal with double defects through in-depth analysis of comparison of numerical and experimental res...
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Article
Open AccessRole of supersaturated Al-C phases in mechanical properties of Al/fullerene composites
We investigated the reinforcing effect of supersaturated Al-C phases on the mechanical properties of Al/C60 composites produced via powder metallurgy followed by thermal treatment. We controlled the fractions of ...
