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Article
Open AccessThe serotonin receptor 3E variant is a risk factor for female IBS-D
Irritable bowel syndrome (IBS) is a gut-brain disorder of multifactorial origin. Evidence of disturbed serotonergic function in IBS accumulated for the 5-HT3 receptor family. 5-HT3Rs are encoded by HTR3 genes and...
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Article
Local immune response to food antigens drives meal-induced abdominal pain
Up to 20% of people worldwide develop gastrointestinal symptoms following a meal1, leading to decreased quality of life, substantial morbidity and high medical costs. Although the interest of both the scientific ...
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Article
Open AccessmiR-16 and miR-103 impact 5-HT4 receptor signalling and correlate with symptom profile in irritable bowel syndrome
Irritable bowel syndrome (IBS) is a gut-brain disorder involving alterations in intestinal sensitivity and motility. Serotonin 5-HT4 receptors are promising candidates in IBS pathophysiology since they regulate g...
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Article
Lessons learned — resolving the enigma of genetic factors in IBS
Genetic studies in IBS range from family and twin studies to candidate gene approaches and genome-wide association studies
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Article
Open AccessNo association between the common calcium-sensing receptor polymorphism rs1801725 and irritable bowel syndrome
The calcium-sensing receptor (CaSR) is a calcium (Ca2+) sensitive G protein-coupled receptor implicated in various biological processes. In particular, it regulates Ca2+/Mg2+- homeostasis and senses interstitial ...
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Article
Widespread non-additive and interaction effects within HLA loci modulate the risk of autoimmune diseases
Soumya Raychaudhuri, Paul de Bakker and colleagues test the non-additive disease contributions of classical HLA alleles to five common autoimmune diseases. In four of the five diseases, they observe highly sig...
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Article
Common variants in the HLA-DQ region confer susceptibility to idiopathic achalasia
Johannes Schumacher and colleagues report the results of a genetic association study of idiopathic achalasia, a rare motility disorder of the esophagus. They show that common variation in the HLA-DQ region is str...