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  1. Article

    Open Access

    The serotonin receptor 3E variant is a risk factor for female IBS-D

    Irritable bowel syndrome (IBS) is a gut-brain disorder of multifactorial origin. Evidence of disturbed serotonergic function in IBS accumulated for the 5-HT3 receptor family. 5-HT3Rs are encoded by HTR3 genes and...

    Nikola Fritz, Sabrina Berens, Yuanjun Dong… in Journal of Molecular Medicine (2022)

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  2. No Access

    Article

    Local immune response to food antigens drives meal-induced abdominal pain

    Up to 20% of people worldwide develop gastrointestinal symptoms following a meal1, leading to decreased quality of life, substantial morbidity and high medical costs. Although the interest of both the scientific ...

    Javier Aguilera-Lizarraga, Morgane V. Florens, Maria Francesca Viola, Piyush Jain… in Nature (2021)

  3. Article

    Open Access

    miR-16 and miR-103 impact 5-HT4 receptor signalling and correlate with symptom profile in irritable bowel syndrome

    Irritable bowel syndrome (IBS) is a gut-brain disorder involving alterations in intestinal sensitivity and motility. Serotonin 5-HT4 receptors are promising candidates in IBS pathophysiology since they regulate g...

    Carolin Wohlfarth, Stefanie Schmitteckert, Janina D. Härtle… in Scientific Reports (2017)

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  4. No Access

    Article

    Lessons learned — resolving the enigma of genetic factors in IBS

  5. Genetic studies in IBS range from family and twin studies to candidate gene approaches and genome-wide association studies

  6. ...

    7. Maria Gazouli, Mira M. Wouters… in Nature Reviews Gastroenterology & Hepatolo… (2016)

  7. Article

    Open Access

    No association between the common calcium-sensing receptor polymorphism rs1801725 and irritable bowel syndrome

    The calcium-sensing receptor (CaSR) is a calcium (Ca2+) sensitive G protein-coupled receptor implicated in various biological processes. In particular, it regulates Ca2+/Mg2+- homeostasis and senses interstitial ...

    Philipp Romero, Stefanie Schmitteckert, Mira M. Wouters… in BMC Medical Genetics (2015)

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  8. No Access

    Article

    Widespread non-additive and interaction effects within HLA loci modulate the risk of autoimmune diseases

    Soumya Raychaudhuri, Paul de Bakker and colleagues test the non-additive disease contributions of classical HLA alleles to five common autoimmune diseases. In four of the five diseases, they observe highly sig...

    Tobias L Lenz, Aaron J Deutsch, Buhm Han, **nli Hu, Yukinori Okada… in Nature Genetics (2015)

  9. No Access

    Article

    Common variants in the HLA-DQ region confer susceptibility to idiopathic achalasia

    Johannes Schumacher and colleagues report the results of a genetic association study of idiopathic achalasia, a rare motility disorder of the esophagus. They show that common variation in the HLA-DQ region is str...

    Ines Gockel, Jessica Becker, Mira M Wouters, Stefan Niebisch… in Nature Genetics (2014)