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  1. Article

    Open Access

    Targeting the actin nucleation promoting factor WASp provides a therapeutic approach for hematopoietic malignancies

    Cancer cells depend on actin cytoskeleton rearrangement to carry out hallmark malignant functions including activation, proliferation, migration and invasiveness. Wiskott–Aldrich Syndrome protein (WASp) is an ...

    Guy Biber, Aviad Ben-Shmuel, Elad Noy, Noah Joseph… in Nature Communications (2021)

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    Article

    Modulation of the intracellular inhibitory checkpoint SHP-1 enhances the antitumor activity of engineered NK cells

    Aviad Ben-Shmuel, Guy Biber, Batel Sabag… in Cellular & Molecular Immunology (2021)

  3. Article

    The global response to the COVID-19 pandemic: how have immunology societies contributed?

    The COVID-19 pandemic is shining a spotlight on the field of immunology like never before. To appreciate the diverse ways in which immunologists have contributed, Nature Reviews Immunology invited the president o...

    Faith Osier, Jenny P. Y. Ting, John Fraser, Bart N. Lambrecht… in Nature Reviews Immunology (2020)

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  4. Article

    Open Access

    A conformational change within the WAVE2 complex regulates its degradation following cellular activation

    WASp family Verprolin-homologous protein-2 (WAVE2), a member of the Wiskott-Aldrich syndrome protein (WASp) family of actin nucleation promoting factors, is a central regulator of actin cytoskeleton polymeriza...

    Noah Joseph, Guy Biber, Sophia Fried, Barak Reicher, Omer Levy… in Scientific Reports (2017)

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  5. No Access

    Article

    Oligomerization of signaling complexes by the multipoint binding of GRB2 to both LAT and SOS1

    Receptor oligomerization is vital for activating intracellular signaling, in part by initiating events that recruit effector and adaptor proteins to sites of active signaling. Whether these distal molecules th...

    Jon C D Houtman, Hiroshi Yamaguchi… in Nature Structural & Molecular Biology (2006)

  6. No Access

    Article

    Dynamic molecular interactions linking the T cell antigen receptor to the actin cytoskeleton

    T cell receptor (TCR) engagement leads to actin polymerization at the site of T cell contact with antigen-presenting cells. Here we have studied the dynamic activity of proteins involved in regulating actin po...

    Mira Barda-Saad, Alex Braiman, Rachel Titerence, Stephen C Bunnell… in Nature Immunology (2005)

  7. No Access

    Article

    The mesenchyme expresses T cell receptor mRNAs: relevance to cell growth control

    The mesenchyme plays a crucial regulatory role in organ formation and maintenance. However, comprehensive molecular characterization of these cells is lacking. We found unexpectedly that primary mesenchyme, as...

    Mira Barda-Saad, Yaron Shav-Tal, Arie Leon Rozenszajn, Michal Cohen… in Oncogene (2002)