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  1. No Access

    Article

    CCR5 closes the temporal window for memory linking

    Real-world memories are formed in a particular context and are often not acquired or recalled in isolation1–5. Time is a key variable in the organization of memories, as events that are experienced close in time ...

    Yang Shen, Miou Zhou, Denise Cai, Daniel Almeida Filho, Giselle Fernandes… in Nature (2022)

  2. No Access

    Article

    Amyloid-β oligomers in the nucleus accumbens decrease motivation via insertion of calcium-permeable AMPA receptors

    It is essential to identify the neuronal mechanisms of Alzheimer’s Disease (AD)-associated neuropsychiatric symptoms, e.g., apathy, before improving the life quality of AD patients. Here, we focused on the nuc...

    Changyong Guo, Di Wen, Yihong Zhang, Richie Mustaklem… in Molecular Psychiatry (2022)

  3. Article

    Open Access

    Hotspots of dendritic spine turnover facilitate clustered spine addition and learning and memory

    Modeling studies suggest that clustered structural plasticity of dendritic spines is an efficient mechanism of information storage in cortical circuits. However, why new clustered spines occur in specific loca...

    Adam C. Frank, Shan Huang, Miou Zhou, Amos Gdalyahu… in Nature Communications (2018)

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  4. No Access

    Article

    A shared neural ensemble links distinct contextual memories encoded close in time

    A similar neural ensemble participates in the encoding of two distinct memories, resulting in the recall of one memory increasing the likelihood of recalling the other, but only if those memories occur very cl...

    Denise J. Cai, Daniel Aharoni, Tristan Shuman, Justin Shobe, Jeremy Biane… in Nature (2016)

  5. No Access

    Article

    Mechanism and treatment for learning and memory deficits in mouse models of Noonan syndrome

    Noonan syndrome (NS) is an autosomal dominant genetic disease that is co-morbid with cognitive deficits in a subset of patients. Using mouse models of NS, a study now shows that the synaptic plasticity and mem...

    Yong-Seok Lee, Dan Ehninger, Miou Zhou, Jun-Young Oh, Minkyung Kang… in Nature Neuroscience (2014)

  6. No Access

    Article

    CREB regulates excitability and the allocation of memory to subsets of neurons in the amygdala

    Silva et al. show that CREB modulates allocation of fear memory to specific cells in the lateral amygdala. Reversibly inactivating a subset of CREB-expressing neurons disrupted memory for tone conditioning. Neuro...

    Yu Zhou, Jaejoon Won, Mikael Guzman Karlsson, Miou Zhou… in Nature Neuroscience (2009)