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Article
Recovery of Rare Earths from Rare-Earth Melt Electrolysis Slag by Mineral Phase Reconstruction
Most rare-earth metals and alloys in the world are produced through molten salt electrolysis, resulting in the creation of a substantial amount of rare-earth melt electrolysis slag (RMES) that contains high le...
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Article
Metabolomics unveil key pathways underlying the synergistic activities of aztreonam and avibactam against multidrug-resistant Escherichia coli
Aztreonam/avibactam is effective against serious infections caused by Gram-negative bacteria including Enterobacterales harboring metallo-β-lactamases. While the utility of this combination has been established i...
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Article
Open AccessSmall animal PET imaging with the 68Ga-labeled pH (low) insertion peptide-like peptide YJL-4 in a triple-negative breast cancer mouse model
The aim of this study was to prepare a novel 68Ga-labeled pH (low) insertion peptide (pHLIP)-like peptide, YJL-4, and determine its value for the early diagnosis of triple-negative breast cancer (TNBC) via in viv...
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Article
Development and Validation of UHPLC-MS/MS Method for Quantifying of Agarotriose: An Application for Pharmacokinetic, Tissue Distribution, and Excretion Studies in Rats
A sensitive, rapid, and robust ultra-high performance liquid chromatography-tandem mass spectrometry (UHPLC-MS/MS) method was established for the first time to quantify agarotriose (A3) in rat plasma, tissues,...
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Article
Regioselective electrochemical radical cascade cyclization of internal alkynes to selenated and trifluoromethylated dihydropyran
Dihydropyran (DHP) compounds are not only found in natural products and bioactive molecules, but also serve as important precursors in organic synthesis. Nonetheless, traditional methods for the construction o...
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Article
Prepare and Mechanism of High Purity Quartz by Alkali Corrosion and Acid Leaching Process Using Vein Quartz
Prepare of high-purity quartz using vein quartz by alkali corrosion and acid leaching processes was investigated in this study. Using alkali corrosion method, the impurities on the surface of quartz particles ...
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Article
Determination of Berberine Hydrochloride and Total Glucosides of Paeony by 1H NMR for Quality Control of Fufang Huangliansu Commercial Products
“Fufang huangliansu” prescription, as a Chinese patent herbal medicine, is widely applied in clinical practice, and its main physiologically active components are berberine hydrochloride and total glucosides o...
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Article
Prediction of Tissue Exposures of Meropenem, Colistin, and Sulbactam in Pediatrics Using Physiologically Based Pharmacokinetic Modeling
The combination of polymyxins, meropenem, and sulbactam demonstrated efficacy against multi-drug-resistant bacillus Acinetobacter baumannii. These three antibiotics are commonly used against major blood, skin, lu...
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Article
Synthesis and Evaluation of Radioiodine-Labeled pH (Low) Insertion Peptide Variant 7-Like Peptide as a Noninvasive Tumor Microenvironment Imaging Agent in a Mouse MDA-MB-231 Triple-Negative Breast Cancer Model
The pH (low) insertion peptide (pHLIP) family can target the tumor microenvironment (TME). If pHLIP can be labeled with radioiodine, the imaging and treatment of tumors can be considered. However, tyrosine and...
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Article
Evaluation of Chito-Oligosaccharide (COS) in Vitro and in Vivo: Permeability Characterization in Caco-2 Cells Monolayer and Pharmacokinetics Properties in Rats
Chito-oligosaccharide (COS) had shown a variety of biological activities and potential biomedical implications. The present study investigated the pharmacokinetics, bioavailability, and in vitro absorption of COS...
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Article
An FDG PET/CT metabolic parameter-based nomogram for predicting the early recurrence of hepatocellular carcinoma after liver transplantation
To construct an FDG PET/CT metabolic parameter-based model to predict early recurrence of hepatocellular carcinoma (HCC) after liver transplantation (LT).
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Article
Colorimetric and Ratiometric Fluorescence Detection of HSO3− With a NIR Fluorescent Dye
Bisulfite (HSO3−) has been widely used in food and industry, which has brought convenience to human life, but also seriously endangered human health. In this work, the probe PBI was designed and synthesized to de...
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Article
Determination of Salidroside and Betaine by 1H NMR for Quality Control of **nnaoxin Commercial Products
A validated and sensitive 1H NMR method was developed for the qualitative and quantitative analysis of the two main components of “xinnaoxin” prescriptions, salidroside and betaine. For the quantitative analysis,...
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Article
Open AccessPharmacodynamic evaluation of suppression of in vitro resistance in Acinetobacter baumannii strains using polymyxin B-based combination therapy
The emergence of polymyxin resistance in Gram-negative bacteria infections has motivated the use of combination therapy. This study determined the mutant selection window (MSW) of polymyxin B alone and in comb...
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Article
Preparation of Yellow Fluorescent N,O-CDs and its Application in Detection of ClO−
Accurate and efficient detection of ClO− was extremely important due to the harm of ROS in the environment and organism. In this paper, yellow fluorescent N,O-CDs were successfully prepared by the solvothermal me...
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Article
Association between selected urinary heavy metals and asthma in adults: a retrospective cross-sectional study of the US National Health and Nutrition Examination Survey
Heavy metal in the physical environment may alter immune function and predispose to develop asthma in human. Our study was aimed to investigate associations between urinary heavy metals and asthma in adults. A...
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Article
Correction to: Additional value of metabolic parameters to PET/CT-based radiomics nomogram in predicting lymphovascular invasion and outcome in lung adenocarcinoma
Figures 1 and 4 are incorrect in the original manuscript.
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Article
Additional value of metabolic parameters to PET/CT-based radiomics nomogram in predicting lymphovascular invasion and outcome in lung adenocarcinoma
Lymphovascular invasion (LVI) impairs surgical outcomes in lung adenocarcinoma (LAC) patients. Preoperative prediction of LVI is challenging by using traditional clinical and imaging parameters. The purpose of...
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Article
1H NMR Quantification of DHA and EPA in Fish Oil
Fish oil is a popular nutritional product consumed in China. The beneficial effects of fish oil have been attributed to docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA). Hence, it is crucial to devel...
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Article
Simultaneous Quantification of κ-Carrageenan Oligosaccharides of DP 3, 5 and 7 by LC-MS/MS: Application to an in vitro Absorption Study
Carrageenans are widely utilized in many commercial applications such as the food and pharmaceutical industry, due to their excellent functional properties. In this study, a sensitive LC-MS/MS method was devel...
