188 Result(s)

Article

N6-methyladenosine modified TGFB2 triggers lipid metabolism reprogramming to confer pancreatic ductal adenocarcinoma gemcitabine resistance

Gemcitabine resistance is a major obstacle to the effectiveness of chemotherapy in pancreatic ductal adenocarcinoma (PDAC). Therefore, new strategies are needed to sensitize cancer cells to gemcitabine. Here, ...

Ming-Jian Ma, Yin-Hao Shi, Zhi-De Liu, Ying-Qin Zhu, Guang-Yin Zhao… in Oncogene (2024)

Article

DEAD-box helicase 17 (DDX17) protects cardiac function by promoting mitochondrial homeostasis in heart failure

DEAD-box helicase 17 (DDX17) is a typical member of the DEAD-box family with transcriptional cofactor activity. Although DDX17 is abundantly expressed in the myocardium, its role in heart is not fully understo...

Ming**g Yan, Junpeng Gao, Ming Lan, Que Wang… in Signal Transduction and Targeted Therapy (2024)

Article

Non-IG::MYC in diffuse large B-cell lymphoma confers variable genomic configurations and MYC transactivation potential

MYC translocation occurs in 8–14% of diffuse large B-cell lymphoma (DLBCL), and may concur with BCL2 and/or BCL6 translocation, known as double-hit (DH) or triple-hit (TH). DLBCL-MYC/BCL2-DH/TH are largely germin...

Chunye Zhang, Ellen Stelloo, Sharon Barrans, Francesco Cucco, Dan Jiang… in Leukemia (2024)

Article

Randomized evaluation of 5-month Ticagrelor monotherapy after 1-month dual-antiplatelet therapy in patients with acute coronary syndrome treated with drug-coated balloons: REC-CAGEFREE II trial rationale and design

Patients treated with drug-coated balloons (DCB) have the theoretical advantage of adopting a low-intensity antiplatelet regimen due to the absence of struts and polymers. Nevertheless, the optimal antiplatele...

Chao Gao, Bin Zhu, Jianzheng Liu, Zhiwei Jiang, Tao Hu… in BMC Cardiovascular Disorders (2024)

Article

SMYD3 promotes endometrial cancer through epigenetic regulation of LIG4/XRCC4/XLF complex in non-homologous end joining repair

Endometrial cancer (EC) stands as one of the most prevalent malignancies affecting the female genital tract, witnessing a rapid surge in incidence globally. Despite the well-established association of histone ...

Yujia Huang, Ming Tang, Zhiyi Hu, Bailian Cai, Guofang Chen, Lijun Jiang… in Oncogenesis (2024)

Article

Circulating secretoneurin level reflects angiographic coronary collateralization in stable angina patients with chronic total occlusion

To investigate the association between circulating secretoneurin (SN) and angiographic coronary collateralization in stable angina patients with chronic coronary total occlusion (CTO).

Zhi Ming Wu, Ke Huang, Yang Dai, Shuai Chen, **ao Qun Wang… in BMC Cardiovascular Disorders (2024)

Article

A patient with acute myocardial infarction with electrocardiogram Aslanger’s pattern

Aslanger’s pattern in electrocardiogram (ECG) indicates that patients may have acute inferior myocardial infarction(AMI) with concomitant critical stenoses on other coronary arteries, which needs to be evaluat...

Ming-hao Liu, Hao Li, Ang Li, Ru Liu, Hai-bo Liu… in BMC Cardiovascular Disorders (2024)

Article

Icariin improves cardiac function and remodeling via the TGF-β1/Smad signaling pathway in rats following myocardial infarction

Postinfarction cardiac remodeling presents a compensatory mechanism aimed at mitigating congestive heart failure. It is distinguished by progressive dilatation and hypertrophy of the ventricular chambers, fibr...

Ji Jia, **ng-an Zhao, Si-ming Tao, Jun-wen Wang… in European Journal of Medical Research (2023)

Article

A real-world case–control study on the efficacy and safety of pulsed field ablation for atrial fibrillation

The primary objective of this study was to evaluate the efficacy and safety of pulsed field ablation in individuals diagnosed with atrial fibrillation.

Ming Yang, Peng-yu Wang, Ying-lu Hao, Mei Liang… in European Journal of Medical Research (2023)

Article

Correction: PBK phosphorylates MSL1 to elicit epigenetic modulation of CD276 in nasopharyngeal carcinoma

Meng-Yao Wang, Bin Qi, Fang Wang, Zhi-Rui Lin, Ming-Yi Li, Wen-**g Yin… in Oncogenesis (2023)

Article

Identification of a potential bioinformatics-based biomarker in keloids and its correlation with immune infiltration

Keloid formation is a pathological consequence resulting from cutaneous irritation and injury, primarily attributed to excessive collagen matrix deposition and fibrous tissue proliferation. Chronic inflammatio...

Zihan Li, Chuwei Zhang, Qingrong Zhang, Yipeng Dong… in European Journal of Medical Research (2023)

Article

P21-activated kinase 1 (PAK1)-mediated cytoskeleton rearrangement promotes SARS-CoV-2 entry and ACE2 autophagic degradation

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the causative agent of coronavirus disease 2019 (COVID-19), has had a significant impact on healthcare systems and economies worldwide. The continu...

Ming Liu, Bingtai Lu, Yue Li, Shuofeng Yuan… in Signal Transduction and Targeted Therapy (2023)

Article

Control status of ambulatory blood pressure and its relationship with arterial stiffness in the China nationwide registry of treated hypertensive patients: the REACTION-ABP study

The control rate of ambulatory blood pressure (BP) is unclear in Chinese hypertensive patients, and whether it would be associated with the ambulatory arterial stiffness indices is also unknown. From June 2018...

Ming-Xuan Li, Dong-Yan Zhang, Song-Tao Tang, Qi-Dong Zheng… in Hypertension Research (2023)

Article

Secreted LRPAP1 binds and triggers IFNAR1 degradation to facilitate virus evasion from cellular innate immunity

The crucial role of interferon (IFN) signaling is well known in the restriction or eradication of pathogen invasion. Viruses take a variety of ways to antagonize host defense through eliminating IFN-signaling ...

Huangcan Li, **ong Wang, Yiran Wang, Yichen Li… in Signal Transduction and Targeted Therapy (2023)

Article

Hypoxia-inducible factor upregulation by roxadustat attenuates drug reward by altering brain iron homoeostasis

Substance use disorder remains a major challenge, with an enduring need to identify and evaluate new, translational targets for effective treatment. Here, we report the upregulation of Hypoxia-inducible factor...

Pengju Yan, Ningning Li, Ming Ma, Zhaoli Liu… in Signal Transduction and Targeted Therapy (2023)

Article

Correction: “The 5th edition of The World Health Organization Classification of Haematolymphoid Tumours: Lymphoid Neoplasms” Leukemia. 2022 Jul;36(7):1720–1748

Rita Alaggio, Catalina Amador, Ioannis Anagnostopoulos, Ayoma D. Attygalle… in Leukemia (2023)

Article

Twelve-month effectiveness of telephone and SMS support to mothers with children aged 2 years in reducing children’s BMI: a randomized controlled trial

Few quality intervention studies have assessed whether a combined telephone and short message service (SMS) intervention to mothers is effective in reducing BMI and obesity risk behaviors of children at 3 year...

Li Ming Wen, Huilan Xu, Philayrath Phongsavan… in International Journal of Obesity (2023)