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Article
Open AccessBiomimetic enantioselective synthesis of β,β-difluoro-α-amino acid derivatives
Although utilization of fluorine compounds has a long history, synthesis of chiral fluorinated amino acid derivatives with structural diversity and high stereoselectivity is still very appealing and challengin...
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Article
Neuroprotective Effects and Mechanisms of Action of Multifunctional Agents Targeting Free Radicals, Monoamine Oxidase B and Cholinesterase in Parkinson’s Disease Model
Parkinson’s disease (PD) is a complex neurodegenerative disorder with multifactorial pathologies, including progressive loss of dopaminergic (DA) neurons, oxidative stress, mitochondrial dysfunction, and incre...
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Article
An unexpected replacement of a methyl with an amino in the tetramethylpyrazine system
A novel and unexpected product, 5-amino-3,6-dimethyl-2-pyrazinecarbonitrile (3), was obtained during the attempted to synthesis of 3,5,6-trimethyl-2-pyrazinecarbonitrile (2) from its corresponding alcohol (1) by ...
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Article
The Novel Tetramethylpyrazine Bis-nitrone (TN-2) Protects Against MPTP/MPP+-Induced Neurotoxicity via Inhibition of Mitochondrial-Dependent Apoptosis
Mitochondrial-dependent apoptosis plays an important role in the degeneration of dopaminergic neurons in Parkinson’s disease (PD). Methyl-4-phenyl-1,2,3,6-tetra- hydropyridine (MPTP), the most widely used neur...
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Article
Open AccessInduction of seed germination in Orobanche spp. by extracts of traditional Chinese medicinal herbs
The co-evolution of Orobanche spp. and their hosts within the same environment has resulted in a high degree of adaptation and effective parasitism whereby the host releases parasite germination stimulants, which...
