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Article
Open AccessEmerging role of senescent microglia in brain aging-related neurodegenerative diseases
Brain aging is a recognized risk factor for neurodegenerative diseases like Alzheimer's disease, Parkinson's disease, and amyotrophic lateral sclerosis (ALS, Lou Gehrig's disease), but the intricate interplay ...
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Article
Open AccessRole of NCKAP1 in the Defective Phagocytic Function of Microglia-Like Cells Derived from Rapidly Progressing Sporadic ALS
Microglia plays a key role in determining the progression of amyotrophic lateral sclerosis (ALS), yet their precise role in ALS has not been identified in humans. This study aimed to identify a key factor rela...
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Article
Open AccessA molecular characterization and clinical relevance of microglia-like cells derived from patients with panic disorder
Few studies report the microglia involvement in the pathogenesis of panic disorder (PD), although the crucial role of microglia in other neuropsychiatric diseases is being emphasized. In addition, there is no ...
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Article
Fluoxetine Decreases Phagocytic Function via REV-ERBα in Microglia
Although fluoxetine (FLX) is a commonly used drug in psychiatric disorders, such as major depressive disorder, anxiety disorder, panic disorder, and obsessive–compulsive disorder, the mechanism by which FLX ex...
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Article
Open AccessMicroglia involvement in sex-dependent behaviors and schizophrenia occurrence in offspring with maternal dexamethasone exposure
Fetal microglia that are particularly sensitive cells to the changes in utero environment might be involved in the sex-biased onset and vulnerability to psychiatric disorders. To address this issue, we administer...
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Article
Advanced therapeutic strategies targeting microglia: beyond neuroinflammation
For a long time, microglia have been recognized as the main culprits of neuroinflammatory responses because they are primary phagocytes present in the parenchyma of the central nervous system (CNS). However, w...
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Article
Persistent Acidic Environment Induces Impaired Phagocytosis via ERK in Microglia
Acidic environment evoked by stroke, traumatic brain injury, and Alzheimer’s disease may change the functional properties of microglia. Nevertheless, the underlying mechanisms of functional changes in microgli...
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Article
Possible role of arginase 1 positive microglia on depressive/anxiety-like behaviors in atopic dermatitis mouse model
Atopic dermatitis (AD) and mood disorder comorbidities are typical, but the exact mechanism underlying their interplay has not been clarified. In this study, we aimed to identify the possible mechanisms of anx...
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Article
Open AccessA new method for obtaining bankable and expandable adult-like microglia in mice
The emerging role of microglia in neurological disorders requires a novel method for obtaining massive amounts of adult microglia. We aim to develop a new method for obtaining bankable and expandable adult-lik...
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Article
Open AccessChronically infused angiotensin II induces depressive-like behavior via microglia activation
Brain inflammation is one of hypotheses explaining complex pathomechanisms of depression. Angiotensin II (ANGII), which is associated with hypertension, also induces brain inflammation. However, there is no an...
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Article
Open AccessHuman umbilical cord-derived mesenchymal stem cells alleviate schizophrenia-relevant behaviors in amphetamine-sensitized mice by inhibiting neuroinflammation
At present, therapeutic options available for treating schizophrenia are limited to monoamine-based antipsychotic drugs. Recent genome wide association study (GWAS) indicated a close relationship between immun...
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Article
Time Course of Peripheral and Central Immune System Alterations in Paclitaxel-Treated Mice: Possible Involvement of Dysfunctional Microglia
Despite the importance of microglial cells in chronic pain, the mechanisms of microglial engagement remain controversial. In this study, we examined the changes in immune-related factors in the mesenteric lymp...
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Article
The International Knee Documentation Committee Score Indicates Midterm Patient Satisfaction with Outcomes after Meniscal Allograft Transplantation
This study aimed to identify the factors associated with patient satisfaction with the outcome of meniscal allograft transplantation (MAT).
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Article
Differential effect of LPS and paclitaxel on microglial functional phenotypes and circulating cytokines: the possible role of CX3CR1 and IL-4/10 in blocking persistent inflammation
Neuroinflammation plays a role in cancer chemotherapy-induced chronic pain. Thus far, most studies have focused on neuroinflammation suppression. However, there are limited reports of which factor is involved ...
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Article
Dexamethasone Induces a Specific Form of Ramified Dysfunctional Microglia
The functional status of dynamic microglial cells plays an important role in maintaining homeostasis of microenvironment in CNS. In a previous study, we reported that microglia phenotype might be involved in s...
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Article
Alpha-Synuclein Suppresses Retinoic Acid-Induced Neuronal Differentiation by Targeting the Glycogen Synthase Kinase-3β/β-Catenin Signaling Pathway
Alpha-synuclein (α-SYN) is expressed during neuronal development and is mainly involved in the modulation of synaptic transmission. Missense mutations and amplifications of this gene have been associated with ...
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Article
Weight-bearing computed tomography findings in varus ankle osteoarthritis: abnormal internal rotation of the talus in the axial plane
To assess the incidence of abnormal internal rotation of the talus in the axial plane in patients with varus ankle osteoarthritis, and to determine whether this incidence differs from the severity of varus ank...
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Article
Open AccessIL-4/10 prevents stress vulnerability following imipramine discontinuation
Identifying stress vulnerability after antidepressant discontinuation may be useful in treating relapses in depression. Previous studies have suggested significant effects of the immune system as well as the c...
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Article
Hypoxia/Reoxygenation-Preconditioned Human Bone Marrow-Derived Mesenchymal Stromal Cells Rescue Ischemic Rat Cortical Neurons by Enhancing Trophic Factor Release
Bone marrow-derived mesenchymal stromal cells (BM-MSCs) represent a promising tool for stem cell-based therapies. However, the majority of MSCs fail to reach the injury site and have only minimal therapeutic e...
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Article
Temporal expression of hippocampal lysophosphatidic acid receptors and their roles in kainic acid-induced neurotoxicity
In this investigation, the role of hippocampal lysophosphatidic acid (LPA) receptors in the regulation of kainic acid (KA)-induced neurotoxicity was investigated. KA (0.07 μg) intracerebroventricular (i.c.v.) ...
