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Article
Open AccessAdaptive Darwinian off-target resistance mechanisms to selective RET inhibition in RET driven cancer
Patients treated with RET protein tyrosine kinase inhibitors (TKIs) selpercatinib or pralsetinib develop RET TKI resistance by secondary RET mutations or alterative oncogenes, of which alterative oncogenes pos...
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Article
Open AccessDevelopment and characterization of efficient xylose utilization strains of Zymomonas mobilis
Efficient use of glucose and xylose is a key for the economic production of lignocellulosic biofuels and biochemicals, and different recombinant strains have been constructed for xylose utilization including t...
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Article
Open AccessRevitalizing the ethanologenic bacterium Zymomonas mobilis for sugar reduction in high-sugar-content fruits and commercial products
The excessive consumption of sugars can cause health issues. Different strategies have been developed to reduce sugars in the diets. However, sugars in fruits and commercial products may be difficult to reduce...
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Article
Open AccessEstablishment and application of a CRISPR–Cas12a assisted genome-editing system in Zymomonas mobilis
Efficient and convenient genome-editing toolkits can expedite genomic research and strain improvement for desirable phenotypes. Zymomonas mobilis is a highly efficient ethanol-producing bacterium with a small gen...
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Article
Open AccessProgress and perspective on lignocellulosic hydrolysate inhibitor tolerance improvement in Zymomonas mobilis
Pretreatment is the key step to overcome the recalcitrance of lignocellulosic biomass making sugars available for subsequent enzymatic hydrolysis and microbial fermentation. During the process of pretreatment ...
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Article
Preoperative Serum Osteocalcin may Predict Postoperative Elevated Parathyroid Hormone in Patients with Primary Hyperparathyroidism
Persistent postoperative elevation of parathyroid hormone (POePTH) following successful parathyroidectomy for primary hyperparathyroidism (PHPT) is presumed to result from bone remineralization. Predicting whi...
