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  1. Article

    Open Access

    Epigenetic alterations are associated with monocyte immune dysfunctions in HIV-1 infection

    Monocytes are key cells in the immune dysregulation observed during human immunodeficiency virus (HIV) infection. The events that take place specifically in monocytes may contribute to the systemic immune dysf...

    Milena S. Espíndola, Luana S. Soares, Leonardo J. Galvão-Lima… in Scientific Reports (2018)

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    Article

    HIV infection: focus on the innate immune cells

    Innate immune cells play a critical role during the onset of HIV infection and remain active until the final events that characterize AIDS. The viral impact on innate immune cell response may be a result of di...

    Milena S. Espíndola, Luana S. Soares, Leonardo J. Galvão-Lima… in Immunologic Research (2016)

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    Article

    Moojenactivase, a novel pro-coagulant PIIId metalloprotease isolated from Bothrops moojeni snake venom, activates coagulation factors II and X and induces tissue factor up-regulation in leukocytes

    Coagulopathies following snakebite are triggered by pro-coagulant venom toxins, in which metalloproteases play a major role in envenomation-induced coagulation disorders by acting on coagulation cascade, plate...

    Marco A. Sartim, Tassia R. Costa, Helen J. Laure… in Archives of Toxicology (2016)

  4. Article

    Open Access

    Mycobacterium tuberculosis expressing phospholipase C subverts PGE2 synthesis and induces necrosis in alveolar macrophages

    Phospholipases C (PLCs) are virulence factors found in several bacteria. In Mycobacterium tuberculosis (Mtb) they exhibit cytotoxic effects on macrophages, but the mechanisms involved in PLC-induced cell death ar...

    Patricia A Assis, Milena S Espíndola, Francisco WG Paula-Silva… in BMC Microbiology (2014)

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