9 Result(s)

Article

Plasma extracellular vesicle tau and TDP-43 as diagnostic biomarkers in FTD and ALS

Minimally invasive biomarkers are urgently needed to detect molecular pathology in frontotemporal dementia (FTD) and amyotrophic lateral sclerosis (ALS). Here, we show that plasma extracellular vesicles (EVs) ...

Madhurima Chatterjee, Selcuk Özdemir, Christian Fritz, Wiebke Möbius… in Nature Medicine (2024)

Article

Longitudinal cognitive decline characterizes the profile of non-PD-manifest GBA1 mutation carriers

With disease-modifying treatment for Parkinson’s disease (PD) associated with variants in the glucocerebrosidase gene (GBA1) under way, the challenge to design clinical trials with non-PD-manifest GBA mutation ca...

Benjamin Roeben, Inga Liepelt-Scarfone, Stefanie Lerche… in npj Parkinson's Disease (2024)

Article

CSF α-synuclein seed amplification kinetic profiles are associated with cognitive decline in Parkinson’s disease

Seed amplification assays have been implemented in Parkinson’s disease to reveal disease-specific misfolded alpha-synuclein aggregates in biospecimens. While the assays’ qualitative dichotomous seeding respons...

Kathrin Brockmann, Stefanie Lerche, Simone Baiardi… in npj Parkinson's Disease (2024)

Article

Seroprevalence of autoimmune antibodies in degenerative ataxias: a broad, disease-controlled screening in 456 subjects

Benjamin Roeben, Madeleine Scharf, Ramona Miske, Bianca Teegen… in Journal of Neurology (2023)

Article

Inflammatory CSF profiles and longitudinal development of cognitive decline in sporadic and GBA-associated PD

Inflammation modifies the incidence and progression of Parkinson’s disease (PD). By using 30 inflammatory markers in CSF in 498 people with PD and 67 people with dementia with Lewy bodies (DLB) we show that: (...

Stefanie Lerche, Milan Zimmermann, Benjamin Roeben… in npj Parkinson's Disease (2023)

Article

Association between CSF alpha-synuclein seeding activity and genetic status in Parkinson’s disease and dementia with Lewy bodies

The clinicopathological heterogeneity in Lewy-body diseases (LBD) highlights the need for pathology-driven biomarkers in-vivo. Misfolded alpha-synuclein (α-Syn) is a lead candidate based on its crucial role in di...

Kathrin Brockmann, Corinne Quadalti… in Acta Neuropathologica Communications (2021)

Article

Arm swing responsiveness to dopaminergic medication in Parkinson’s disease depends on task complexity

The evidence of the responsiveness of dopaminergic medication on gait in patients with Parkinson’s disease is contradicting. This could be due to differences in complexity of the context gait was in performed....

Elke Warmerdam, Robbin Romijnders, Clint Hansen, Morad Elshehabi… in npj Parkinson's Disease (2021)

Article

Typology of murder-suicides in Berlin according to a longitudinal study based on autopsy files

Murder-suicides are defined as the murder of at least one person and the suicide of the offender following the murder. The intention to commit suicide must be primary. In most cases, a male offender kills a f...

Milan Zimmermann, Michael Tsokos in Forensic Science, Medicine and Pathology (2021)

Article

Tetraparesis and sensorimotor axonal polyneuropathy due to co-occurrence of Pompe disease and hereditary ATTR amyloidosis

Hereditary transthyretin amyloidosis with polyneuropathy (hATTRPN) is an autosomal dominant multi-organ disorder manifesting in the third to fifth decade with the key clinical features of distal and painful se...

Milan Zimmermann, Natalie Deininger, Sophia Willikens… in Neurological Sciences (2021)