24 Result(s)

Article

Author Correction: FinnGen provides genetic insights from a well-phenotyped isolated population

Mitja I. Kurki, Juha Karjalainen, Priit Palta, Timo P. Sipilä, Kati Kristiansson… in Nature (2023)

Article

FinnGen provides genetic insights from a well-phenotyped isolated population

Population isolates such as those in Finland benefit genetic research because deleterious alleles are often concentrated on a small number of low-frequency variants (0.1% ≤ minor allele frequency < 5%). These ...

Mitja I. Kurki, Juha Karjalainen, Priit Palta, Timo P. Sipilä, Kati Kristiansson… in Nature (2023)

Article

Succession of physiological stages hallmarks the transcriptomic response of the fungus Aspergillus niger to lignocellulose

Understanding how fungi degrade lignocellulose is a cornerstone of improving renewables-based biotechnology, in particular for the production of hydrolytic enzymes. Considerable progress has been made in inves...

Jolanda M. van Munster, Paul Daly, Martin J. Blythe… in Biotechnology for Biofuels (2020)

Article

A community-driven reconstruction of the Aspergillus niger metabolic network

Aspergillus niger is an important fungus used in industrial applications for enzyme and acid production. To enable rational metabolic engineering of the species, available information can be collected and integra...

Julian Brandl, Maria Victoria Aguilar-Pontes… in Fungal Biology and Biotechnology (2018)

Article

Genome Sequencing and analyses of Two Marine Fungi from the North Sea Unraveled a Plethora of Novel Biosynthetic Gene Clusters

Marine Fungi are potent secondary metabolite producers. However, limited genetic information are available their biosynthetic gene clusters (BGCs) and their biotechnological applications. To overcome this lack...

Abhishek Kumar, Jens Laurids Sørensen, Frederik Teilfeldt Hansen… in Scientific Reports (2018)

Article

Characterization of sulfhydryl oxidase from Aspergillus tubingensis

Despite of the presence of sulfhydryl oxidases (SOXs) in the secretomes of industrially relevant organisms and their many potential applications, only few of these enzymes have been biochemically characterized...

Outi Nivala, Greta Faccio, Mikko Arvas, Perttu Permi, Johanna Buchert… in BMC Biochemistry (2017)

Article

Whole-genome metabolic model of Trichoderma reesei built by comparative reconstruction

Trichoderma reesei is one of the main sources of biomass-hydrolyzing enzymes for the biotechnology industry. There is a need for improving its enzyme production efficiency. The use of ...

Sandra Castillo, Dorothee Barth, Mikko Arvas, Tiina M. Pakula… in Biotechnology for Biofuels (2016)

Article

Ploidy influences the functional attributes of de novo lager yeast hybrids

The genomes of hybrid organisms, such as lager yeast (Saccharomyces cerevisiae × Saccharomyces eubayanus), contain orthologous genes, the functionality and effect of which may differ depending on their origin and...

Kristoffer Krogerus, Mikko Arvas… in Applied Microbiology and Biotechnology (2016)

Article

Genome wide analysis of protein production load in Trichoderma reesei

The filamentous fungus Trichoderma reesei (teleomorph Hypocrea jecorina) is a widely used industrial host organism for protein production. In industrial cultivations, it can produce over 100 g/l of extracellular ...

Tiina M. Pakula, Heli Nygren, Dorothee Barth, Markus Heinonen… in Biotechnology for Biofuels (2016)

Article

A novel pathway for fungal D-glucuronate catabolism contains an L-idonate forming 2-keto-L-gulonate reductase

For the catabolism of D-glucuronate, different pathways are used by different life forms. The pathways in bacteria and animals are established, however, a fungal pathway has not been described. In this communi...

Joosu Kuivanen, Maura H. Sugai-Guérios, Mikko Arvas, Peter Richard in Scientific Reports (2016)

Article

Investigation of protein secretion and secretion stress in Ashbya gossypii

Ashbya gossypii is a filamentous Saccharomycete used for the industrial production of riboflavin that has been recently explored as a host system for recombinant protein production. To gain insight into the prote...

Tatiana Q Aguiar, Orquídea Ribeiro, Mikko Arvas, Marilyn G Wiebe… in BMC Genomics (2014)

Article

Screening of candidate regulators for cellulase and hemicellulase production in Trichoderma reesei and identification of a factor essential for cellulase production

The soft rot ascomycetal fungus Trichoderma reesei is utilized for industrial production of secreted enzymes, especially lignocellulose degrading enzymes. T. reesei uses several different enzymes for the degradat...

Mari Häkkinen, Mari J Valkonen, Ann Westerholm-Parvinen… in Biotechnology for Biofuels (2014)

Article

Re-annotation of the CAZy genes of Trichoderma reesei and transcription in the presence of lignocellulosic substrates

Trichoderma reesei is a soft rot Ascomycota fungus utilised for industrial production of secreted enzymes, especially lignocellulose degrading enzymes. About 30 carbohydrate active enzymes (CAZymes) of T. reesei ...

Mari Häkkinen, Mikko Arvas, Merja Oja, Nina Aro, Merja Penttilä… in Microbial Cell Factories (2012)

Article

Correlation of gene expression and protein production rate - a system wide study

Growth rate is a major determinant of intracellular function. However its effects can only be properly dissected with technically demanding chemostat cultivations in which it can be controlled. Recent work on Sac...

Mikko Arvas, Tiina Pakula, Bart Smit, Jari Rautio, Heini Koivistoinen… in BMC Genomics (2011)

Article

Erratum to: Discovery of a new tyrosinase-like enzyme family lacking a C-terminally processed domain: production and characterization of an Aspergillus oryzae catechol oxidase

Chiara Gasparetti, Greta Faccio, Mikko Arvas… in Applied Microbiology and Biotechnology (2011)

Article

Array comparative genomic hybridization analysis of Trichoderma reesei strains with enhanced cellulase production properties

Trichoderma reesei is the main industrial producer of cellulases and hemicellulases that are used to depolymerize biomass in a variety of biotechnical applications. Many of the production strains currently in use...

Marika Vitikainen, Mikko Arvas, Tiina Pakula, Merja Oja, Merja Penttilä… in BMC Genomics (2010)

Article

Correction: Corrigendum: Genome sequencing and analysis of the biomass-degrading fungus Trichoderma reesei (syn. Hypocrea jecorina)

Nat. Biotechnol. 26, 553–560 (2008); published online 4 May 2008; corrected after print 9 October 2008. In the version of this article initially published, an author's name was misspelled as Barbote. The corre...

Diego Martinez, Randy M Berka, Bernard Henrissat, Markku Saloheimo… in Nature Biotechnology (2008)