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Article
Development of TCR-T cell therapy targeting mismatched HLA-DPB1 for relapsed leukemia after allogeneic transplantation
Relapsed leukemia after allogeneic hematopoietic stem cell transplantation (allo-HSCT) remains a significant challenge, with the re-emergence of the primary disease being the most frequent cause of death. Huma...
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Article
A multicenter phase I study of inebilizumab, a humanized anti-CD19 monoclonal antibody, in Japanese patients with relapsed or refractory B-cell lymphoma and multiple myeloma
This multicenter, phase I, open-label dose escalation study evaluated safety, tolerability, pharmacokinetics, and preliminary anti-tumor activity of inebilizumab in Japanese patients with relapsed/refractory d...
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Article
Open AccessZinc deficiency causes delayed ATP clearance and adenosine generation in rats and cell culture models
Zinc deficiency causes myriad pathophysiological symptoms, but why distinct phenotypes are generated by zinc deficiency remains unclear. Considering that several ectoenzymes involved in purinergic signaling th...
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Article
Open AccessGenome-wide association study in Japanese females identifies fifteen novel skin-related trait associations
Skin trait variation impacts quality-of-life, especially for females from the viewpoint of beauty. To investigate genetic variation related to these traits, we conducted a GWAS of various skin phenotypes in 11...
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Article
Open AccessJapanese GWAS identifies variants for bust-size, dysmenorrhea, and menstrual fever that are eQTLs for relevant protein-coding or long non-coding RNAs
Traits related to primary and secondary sexual characteristics greatly impact females during puberty and day-to-day adult life. Therefore, we performed a GWAS analysis of 11,348 Japanese female volunteers and ...
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Article
Open AccessGenome-wide association study of self-reported food reactions in Japanese identifies shrimp and peach specific loci in the HLA-DR/DQ gene region
Food allergy is an increasingly important health problem in the world. Several genome-wide association studies (GWAS) focused on European ancestry samples have identified food allergy-specific loci in the HLA ...
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Article
Use of fertilized molten slags to create Sargassum forests in subtropical shallow waters
Recently, a solid fertilizer with condensed nutrients was manufactured using molten slag from municipal solid waste and dried cow dung. This novel substratum was used for the afforestation of Sargassum alternato-...
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Article
Open AccessBreastfeeding practices and parental employment in Japan
Much research shows that breastfeeding provides short- and long-term health benefits for both mothers and their children. However, few studies have yet investigated the factors which may promote or inhibit bre...
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Article
Open AccessSharing housework between husbands and wives: how to improve marital satisfaction for working wives in Japan
This paper examines whether and how the marital satisfaction of Japanese couples is related to the housework the spouse performs. For single-earner couples, both husbands and wives are more satisfied with the ...
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Article
Sinomenine and magnoflorine, major constituents of Sinomeni Caulis et Rhizoma, show potent protective effects against membrane damage induced by lysophosphatidylcholine in rat erythrocytes
The effects of the water extract of Sinomeni Caulis et Rhizoma (SCR-WE) and its major constituents, sinomenine (SIN) and magnoflorine (MAG), on moderate hemolysis induced by lysophosphatidylcholine (LPC) were inv...
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Article
Phenology of annual kelp Eckloniopsis (Phaeophyceae, Laminariales) forest on a Diadema barren in Uchiura Bay, Central Pacific Coast of Honshu, Japan
On the southern coast of Uchiura Bay, central Pacific, Japan, Diadema barrens have expanded since the 1980s but Eckloniopsis radicosa (annual kelp endemic to Japan) has remained in deeper waters (>10 m in depth)....
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Article
Can thallus color of red algae be used as an environmental indicator in shallow waters?
Red algae sometimes turn yellow, but few studies have been conducted on the yellowing of subtidal bed-forming species and on the relationship between the color and environmental factors. We examined the season...
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Article
Division of Household Labor and Marital Satisfaction in China, Japan, and Korea
In this study, we compared the association of marital satisfaction with the division of household labor in China, Japan, and Korea. Results revealed that wives’ marital satisfaction was negatively associated w...
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Article
Relative Income and Happiness in Asia: Evidence from Nationwide Surveys in China, Japan, and Korea
This study attempts to examine relative income effects on perceived happiness in three major Asian countries—China, Japan, and Korea—in comparison with the United Sates, on the basis of largely comparable nati...
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Article
Area-Level Income Inequality and Individual Happiness: Evidence from Japan
In this study, we investigated how area-level income inequality is associated with an individual’s assessment of happiness, based on micro-level data sourced from nationwide surveys in Japan. It was confirmed ...
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Article
A novel insertion mutation of K294RGG within BCR-ABL kinase domain confers imatinib resistance: sequential analysis of the clonal evolution in a patient with chronic myeloid leukemia in blast crisis
BCR-ABL kinase domain mutations were sequentially analyzed in a patient with chronic myeloid leukemia (CML) who exhibited repeated B-lymphoid blast crisis (CML-BC) during treatment with imatinib and dasatinib. We...
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Article
Child Poverty as a Determinant of Life Outcomes: Evidence from Nationwide Surveys in Japan
We attempt to examine the extent to which poverty in childhood adversely affects success in adulthood, using micro data from nationwide surveys in Japan and taking into account the recursive structure of life ...
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Article
Human protein factory for converting the transcriptome into an in vitro–expressed proteome
A collection of 33,275 human Gateway entry clones and complementary in vitro protein expression methodologies are described that allow proteome-scale production of human proteins. This 'human protein factory' was...
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Article
Mutational analysis of SOS1 gene in acute myeloid leukemia
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Article
Pharmacokinetics of arsenic species in Japanese patients with relapsed or refractory acute promyelocytic leukemia treated with arsenic trioxide
To investigate the pharmacokinetics of arsenic species in Japanese patients with relapsed or refractory acute promyelocytic leukemia (APL) treated with arsenic trioxide (ATO) at a daily dose of 0.15 mg/kg.
