96 Result(s)
within
Mika Kivimäki
English
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Article
Severe infections as a gateway to dementia
A study in Nature Aging on electronic health records from 1.7 million people in New Zealand reveals that most patients with dementia have a history of hospital-treated infection. In a dementia-free population, in...
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Article
Biological aging as a predictor of cardiometabolic multimorbidity
Recent analyses of observational data from 340,000 UK Biobank participants indicate that people with a higher biological age than their same-aged peers have an increased risk of develo** cardiometabolic dise...
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Open AccessThe Semmelweis Study: a longitudinal occupational cohort study within the framework of the Semmelweis Caring University Model Program for supporting healthy aging
The Semmelweis Study is a prospective occupational cohort study that seeks to enroll all employees of Semmelweis University (Budapest, Hungary) aged 25 years and older, with a population of 8866 people, 70.5% ...
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Open AccessIdentification of circulating proteins associated with general cognitive function among middle-aged and older adults
Identifying circulating proteins associated with cognitive function may point to biomarkers and molecular process of cognitive impairment. Few studies have investigated the association between circulating prot...
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Social participation and risk of develo** dementia
The increasing number of people with dementia globally illustrates the urgent need to reduce dementia’s scale and impact. Lifetime social participation may affect dementia risk by increasing cognitive reserve,...
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Open AccessPredicting work disability among people with chronic conditions: a prospective cohort study
Few risk prediction scores are available to identify people at increased risk of work disability, particularly for those with an existing morbidity. We examined the predictive performance of disability risk sc...
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The multiple roles of life stress in metabolic disorders
The activation of stress-related neuroendocrine systems helps to maintain homeostasis, but excessive stress can damage body functions. We review current evidence from basic sciences and epidemiology linking st...
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Open AccessImmune system-wide Mendelian randomization and triangulation analyses support autoimmunity as a modifiable component in dementia-causing diseases
Immune system and blood–brain barrier dysfunction are implicated in the development of Alzheimer’s and other dementia-causing diseases, but their causal role remains unknown. We performed Mendelian randomizati...
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Open AccessWhy do men extend their employment beyond pensionable age more often than women? a cohort study
Men extend their employment beyond pensionable age more often than women, but the factors that contribute to this sex difference are unknown. This study aimed to examine sex differences in extending employment...
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Open AccessPsychosocial work environment as a dynamic network: a multi-wave cohort study
While characteristics of psychosocial work environment have traditionally been studied separately, we propose an alternative approach that treats psychosocial factors as interacting elements in networks where ...
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Open AccessAssociation of plasma gelsolin with frailty phenotype and mortality among octogenarian community-dwelling men: a cohort study
Biomarkers are needed for frailty, a common phenotype often associated with muscle loss in older people. Plasma gelsolin (pGSN) is a protein largely synthesized and secreted by skeletal muscle.
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Open AccessWork stress and loss of years lived without chronic disease: an 18-year follow-up of 1.5 million employees in Denmark
We aimed to examine the association between exposure to work stress and chronic disease incidence and loss of chronic disease-free life years in the Danish workforce. The study population included 1,592,491 em...
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Prevalence of type 2 diabetes in psychiatric disorders: an umbrella review with meta-analysis of 245 observational studies from 32 systematic reviews
Estimates of the global prevalence of type 2 diabetes vary between 6% and 9%. The prevalence of type 2 diabetes has been investigated in psychiatric populations but a critical appraisal of the existing evidenc...
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Open Access‘Return to Work’ Coordinator Model and Work Participation of Employees: A Natural Intervention Study in Finland
Purpose Employers increasingly use ‘return to work’ (RTW) coordinators to support work ability and extend working careers, particularly among employees with reduced work ability. We examined whether applying this...
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Open AccessLength of exposure to long working hours and night work and risk of sickness absence: a register-based cohort study
There is inconsistent evidence that long working hours and night work are risk factors for sickness absence, but few studies have considered variation in the length of exposure time window as a potential sourc...
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Open AccessPhenotypic frailty and multimorbidity are independent 18-year mortality risk indicators in older men
Multimorbidity, phenotypic prefrailty and frailty are frequent in ageing populations
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Correction: Healthy dietary indices and risk of depressive outcomes: a systematic review and meta-analysis of observational studies
A Correction to this paper has been published: https://doi.org/10.1038/s41380-021-01056-7
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Open AccessAlternative duty work as workplace-initiated procedure to reduce sickness absence
Alternative duty work is a procedure that enables an employee with a short-term disability to perform modified duties as an alternative to sickness absence. We examined whether the implementation of an alterna...
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Open AccessAssociations of coffee drinking with physical performance in the oldest-old community-dwelling men The Helsinki Businessmen Study (HBS)
Habitual coffee drinking has been associated with lower risk of various chronic diseases linked to poor physical performance.
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Open AccessAssociation of sleep duration in middle and old age with incidence of dementia
Sleep dysregulation is a feature of dementia but it remains unclear whether sleep duration prior to old age is associated with dementia incidence. Using data from 7959 participants of the Whitehall II study, w...
