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Open AccessPredicting work disability among people with chronic conditions: a prospective cohort study
Few risk prediction scores are available to identify people at increased risk of work disability, particularly for those with an existing morbidity. We examined the predictive performance of disability risk sc...
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Open AccessPsychosocial work environment as a dynamic network: a multi-wave cohort study
While characteristics of psychosocial work environment have traditionally been studied separately, we propose an alternative approach that treats psychosocial factors as interacting elements in networks where ...
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Open AccessAssociation of sleep duration in middle and old age with incidence of dementia
Sleep dysregulation is a feature of dementia but it remains unclear whether sleep duration prior to old age is associated with dementia incidence. Using data from 7959 participants of the Whitehall II study, w...
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Open AccessGene regulation contributes to explain the impact of early life socioeconomic disadvantage on adult inflammatory levels in two cohort studies
Individuals experiencing socioeconomic disadvantage in childhood have a higher rate of inflammation-related diseases decades later. Little is known about the mechanisms linking early life experiences to the fu...
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Open AccessThe association between accelerometer-assessed physical activity and respiratory function in older adults differs between smokers and non-smokers
The association between physical activity and lung function is thought to depend on smoking history but most previous research uses self-reported measures of physical activity. This cross-sectional study inves...
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Open AccessMulti-cohort study identifies social determinants of systemic inflammation over the life course
Chronic inflammation has been proposed as having a prominent role in the construction of social inequalities in health. Disentangling the effects of early life and adulthood social disadvantage on inflammation...
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Open AccessAuthor Correction: Development and validation of a risk prediction model for work disability: multicohort study
A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has not been fixed in the paper.
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Article
Open AccessAssociation of circulating metabolites with healthy diet and risk of cardiovascular disease: analysis of two cohort studies
Diet may modify metabolomic profiles towards higher or lower cardiovascular disease (CVD) risk. We aimed to identify metabolite profiles associated with high adherence to dietary recommendations - the Alternat...
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Open AccessAllostatic load as a predictor of grey matter volume and white matter integrity in old age: The Whitehall II MRI study
The allostatic load index quantifies the cumulative multisystem physiological response to chronic everyday stress, and includes cardiovascular, metabolic and inflammatory measures. Despite its central role in ...
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Open AccessDevelopment and validation of a risk prediction model for work disability: multicohort study
Work disability affects quality of life, earnings, and opportunities to contribute to society. Work characteristics, lifestyle and sociodemographic factors have been associated with the risk of work disability...
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Open AccessWork stress, anthropometry, lung function, blood pressure, and blood-based biomarkers: a cross-sectional study of 43,593 French men and women
Work stress is a risk factor for cardio-metabolic diseases, but few large-scale studies have examined the clinical profile of individuals with work stress. To address this limitation, we conducted a cross-sect...
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Open AccessWork disability before and after a major cardiovascular event: a ten-year study using nationwide medical and insurance registers
We examined the trajectories of work disability before and after IHD and stroke events. New IHD (n = 13521) and stroke (n = 7162) cases in 2006–2008 were retrieved from nationwide Swedish hospital records and ...
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Open AccessLifecourse socioeconomic status and type 2 diabetes: the role of chronic inflammation in the English Longitudinal Study of Ageing
We examined the association between lifecourse socioeconomic status (SES) and the risk of type 2 diabetes at older ages, ascertaining the extent to which adult lifestyle factors and systemic inflammation expla...