8 Result(s)
within
Mika Kivimäki
Life Sciences
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Article
Severe infections as a gateway to dementia
A study in Nature Aging on electronic health records from 1.7 million people in New Zealand reveals that most patients with dementia have a history of hospital-treated infection. In a dementia-free population, in...
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Article
Biological aging as a predictor of cardiometabolic multimorbidity
Recent analyses of observational data from 340,000 UK Biobank participants indicate that people with a higher biological age than their same-aged peers have an increased risk of develo** cardiometabolic dise...
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Article
Open AccessThe Semmelweis Study: a longitudinal occupational cohort study within the framework of the Semmelweis Caring University Model Program for supporting healthy aging
The Semmelweis Study is a prospective occupational cohort study that seeks to enroll all employees of Semmelweis University (Budapest, Hungary) aged 25 years and older, with a population of 8866 people, 70.5% ...
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Article
Open AccessIdentification of circulating proteins associated with general cognitive function among middle-aged and older adults
Identifying circulating proteins associated with cognitive function may point to biomarkers and molecular process of cognitive impairment. Few studies have investigated the association between circulating prot...
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Social participation and risk of develo** dementia
The increasing number of people with dementia globally illustrates the urgent need to reduce dementia’s scale and impact. Lifetime social participation may affect dementia risk by increasing cognitive reserve,...
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Open AccessImmune system-wide Mendelian randomization and triangulation analyses support autoimmunity as a modifiable component in dementia-causing diseases
Immune system and blood–brain barrier dysfunction are implicated in the development of Alzheimer’s and other dementia-causing diseases, but their causal role remains unknown. We performed Mendelian randomizati...
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Open AccessValidating a widely used measure of frailty: are all sub-components necessary? Evidence from the Whitehall II cohort study
There is growing interest in the measurement of frailty in older age. The most widely used measure (Fried) characterizes this syndrome using five components: exhaustion, physical activity, walking speed, grip ...
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Article
The importance of cognitive ageing for understanding dementia
A third of those over 80 years of age are likely to have dementia, the lack of a cure requires efforts directed at prevention and delaying the age of onset. We argue here for the importance of understanding th...
