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  1. No Access

    Chapter

    The ABC of Stem Cell Therapies for Neurological Disorders

    Several neurological conditions may result in permanent or progressive injury to the nervous system, and one promising manner to alleviate this damage is through the use of cell-based therapies. Even though ma...

    Miguel A. Pappolla, ** Wu… in Essentials of Regenerative Medicine in Int… (2024)

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    Article

    Insulysin Cleaves the APP Cytoplasmic Fragment at Multiple Sites

    The amyloid peptide (Aβ) deposited in Alzheimer’s disease (AD) is generated by β- and γ-secretase processing of a larger integral membrane protein precursor (APP). Intramembrane processing of APP by γ-secretas...

    Chitra Venugopal, Miguel A. Pappolla, Kumar Sambamurti in Neurochemical Research (2007)

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    Article

    β-secretase processing of the Alzheimer’s amyloid protein precursor (APP)

    An integral membrane aspartyl protease, BACE, is responsible for β-secretase processing of the β-amyloid precursor protein (APP) to the large secreted sAPPβ and membrane-bound CTFβ of 99 residues. CTFβ is subs...

    Laura Marlow, Melissa Cain, Miguel A. Pappolla… in Journal of Molecular Neuroscience (2003)

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    Article

    Development of indole-3-propionic acid (OXIGON™) for alzheimer’s disease

    The accumulation of amyloid-beta and concomitant oxidative stress are major pathogenic events in Alzheimer’s disease. Indole-3-propionic acid (IPA, OXIGON™) is a potent anti-oxidant devoid of pro-oxidant activ...

    Paul E. Bendheim, Burkhard Poeggeler, Eyal Neria… in Journal of Molecular Neuroscience (2002)

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    Article

    Systemic complement depletion reduces inflammation and demyelination in adoptive transfer experimental allergic neuritis

    The effect of systemic complement depletion by cobra venom factor (CVF) was evaluated in adoptive transfer experimental allergic neuritis (AT-EAN). Spleen cells of rats immunized with a neuritogenic peptide S...

    F. J. Vriesendorp, Robyn E. Flynn, Michael R. Malone… in Acta Neuropathologica (1998)

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    Article

    Ultrastructural evidence that insoluble microtubules are components of the neurofibrillary tangle

    The ultrastructure of Alzheimer's neurofibrillary tangles is heterogeneous and includes abnormal paired helical filaments (PHF) and various other insoluble structures. Insoluble non-PHF components isolated fro...

    Miguel A. Pappolla, Julia Alzofon… in European archives of psychiatry and neurol… (1990)

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    Article

    Aging of the neuroendocrine system: Impaired neuropeptide control of thyroid stimulating hormone

    Previous studies on neuroendocrine feedback control have shown that normal pituitary-thyroid function depends on appropriate hypothalamic regulation. Yet, mechanisms leading to low thyroid stimulating hormone ...

    Theodor J. Theodoropolous, Miguel A. Pappolla in AGE (1990)