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Article
Open AccessA topographic atlas defines developmental origins of cell heterogeneity in the human embryonic lung
The lung contains numerous specialized cell types with distinct roles in tissue function and integrity. To clarify the origins and mechanisms generating cell heterogeneity, we created a comprehensive topograph...
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Article
Open AccessSingle-cell and spatial transcriptomics enables probabilistic inference of cell type topography
The field of spatial transcriptomics is rapidly expanding, and with it the repertoire of available technologies. However, several of the transcriptome-wide spatial assays do not operate on a single cell level,...
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Article
Open AccessTranscriptomics of cardiac biopsies reveals differences in patients with or without diagnostic parameters for heart failure with preserved ejection fraction
Heart failure affects 2–3% of adult Western population. Prevalence of heart failure with preserved left ventricular (LV) ejection fraction (HFpEF) increases. Studies suggest HFpEF patients to have altered myoc...
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Article
Open AccessSpatial detection of fetal marker genes expressed at low level in adult human heart tissue
Heart failure is a major health problem linked to poor quality of life and high mortality rates. Hence, novel biomarkers, such as fetal marker genes with low expression levels, could potentially differentiate ...
