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    Reference Work Entry In depth

    Tregs

    Regulatory T cells (Tregs) are a subtype of T cells with immune suppressive function and play a key role in immune self-tolerance. Its immune inhibitory function has been implicated as the important mechanism ...

    Jong Chul Park, Michael. B. Atkins in Cancer Therapeutic Targets (2017)

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    Living Reference Work Entry In depth

    Tregs

    Regulatory T cells (Tregs) are a subtype of T cells with immune suppressive function and play a key role in immune self-tolerance. Its immune inhibitory function has been implicated as the important mechanism ...

    Jong Chul Park, Michael B. Atkins in Cancer Therapeutic Targets

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    Article

    Induction of circulating tumor necrosis factor (TNFα) as the mechanism for the febrile response to interleukin-2 (IL-2) in cancer patients

    Fever is frequently observed in cancer patients treated with high-dose recombinant human interleukin-2 (rIL-2). The preincubation of rIL-2 with polymyxin B, an antibiotic that inhibits the biologic effects of ...

    James W. Mier, Gloria Vachino, Jos W. M. van der Meer… in Journal of Clinical Immunology (1988)

  4. Article

    The development of anti-interleukin-2 antibodies in patients treated with recombinant human interleukin-2 (IL-2)

    Approximately 65% (11/17) of cancer patients participating in an ongoing Phase I clinical trial with recombinant interleukin-2 developed nonneutralizing serum IgG anti-interleukin-2 antibodies within 1 month o...

    Mark Allegretta, Michael B. Atkins, Roy A. Dempsey… in Journal of Clinical Immunology (1986)

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