70 Result(s)

Article

Author Correction: Transmission of trained immunity and heterologous resistance to infections across generations

Natalie Katzmarski, Jorge Domínguez-Andrés, Branko Cirovic… in Nature Immunology (2023)

Article

Reply to: ‘Lack of evidence for intergenerational inheritance of immune resistance to infections’

Natalie Katzmarski, Jorge Domínguez-Andrés, Branko Cirovic… in Nature Immunology (2022)

Article

A guide to immunotherapy for COVID-19

Immune dysregulation is an important component of the pathophysiology of COVID-19. A large body of literature has reported the effect of immune-based therapies in patients with COVID-19, with some remarkable s...

Frank L. van de Veerdonk, Evangelos Giamarellos-Bourboulis… in Nature Medicine (2022)

Article

Author Correction: Trained immunity, tolerance, priming and differentiation: distinct immunological processes

Maziar Divangahi, Peter Aaby, Shabaana Abdul Khader, Luis B. Barreiro… in Nature Immunology (2021)

Article

Author Correction: A guiding map for inflammation

A Correction to this paper has been published: https://doi.org/10.1038/ni.3790

Mihai G. Netea, Frances Balkwill, Michel Chonchol, Fabio Cominelli… in Nature Immunology (2021)

Article

Trained immunity, tolerance, priming and differentiation: distinct immunological processes

The similarities and differences between trained immunity and other immune processes are the subject of intense interrogation. Therefore, a consensus on the definition of trained immunity in both in vitro and ...

Maziar Divangahi, Peter Aaby, Shabaana Abdul Khader, Luis B. Barreiro… in Nature Immunology (2021)

Article

Multi-omics examination of Q fever fatigue syndrome identifies similarities with chronic fatigue syndrome

Q fever fatigue syndrome (QFS) is characterised by a state of prolonged fatigue that is seen in 20% of acute Q fever infections and has major health-related consequences. The molecular mechanisms underlying QF...

Ruud P. H. Raijmakers, Megan E. Roerink… in Journal of Translational Medicine (2020)

Article

Validity, reliability and feasibility of a new observation rating tool and a post encounter rating tool for the assessment of clinical reasoning skills of medical students during their internal medicine clerkship: a pilot study

Systematic assessment of clinical reasoning skills of medical students in clinical practice is very difficult. This is partly caused by the lack of understanding of the fundamental mechanisms underlying the pr...

Catharina M. Haring, Claudia C. R. Klaarwater, Geert A. Bouwmans… in BMC Medical Education (2020)

Article

Defining trained immunity and its role in health and disease

Immune memory is a defining feature of the acquired immune system, but activation of the innate immune system can also result in enhanced responsiveness to subsequent triggers. This process has been termed ‘tr...

Mihai G. Netea, Jorge Domínguez-Andrés, Luis B. Barreiro… in Nature Reviews Immunology (2020)

Article

A possible role for mitochondrial-derived peptides humanin and MOTS-c in patients with Q fever fatigue syndrome and chronic fatigue syndrome

Q fever fatigue syndrome (QFS) is a well-documented state of prolonged fatigue following around 20% of acute Q fever infections. It has been hypothesized that low grade inflammation plays a role in its aetiolo...

Ruud P. H. Raijmakers, Anne F. M. Jansen… in Journal of Translational Medicine (2019)

Article

Interferon-γ and CXCL10 responses related to complaints in patients with Q fever fatigue syndrome

Approximately 20% of patients with acute Q fever develop Q fever fatigue syndrome (QFS), a debilitating fatigue syndrome. This study further investigates the role of C. burnetii-specific IFNγ, but also IL-2, CXCL...

Ruud P. H. Raijmakers, Anne F. M. Jansen… in European Journal of Clinical Microbiology … (2018)

Article

Cytokine signatures in chronic fatigue syndrome patients: a Case Control Study and the effect of anakinra treatment

Cytokine disturbances have been suggested to be associated with the Chronic Fatigue Syndrome/Myalgic encephalomyelitis (CFS/ME) for decades.

Megan E. Roerink, Hans Knoop, Ewald M. Bronkhorst… in Journal of Translational Medicine (2017)

Article

Observable phenomena that reveal medical students' clinical reasoning ability during expert assessment of their history taking: a qualitative study

During their clerkships, medical students are meant to expand their clinical reasoning skills during their patient encounters. Observation of these encounters could reveal important information on the students...

Catharina M. Haring, Bernadette M. Cools, Petra J. M. van Gurp… in BMC Medical Education (2017)

Article

Interleukin-1 as a mediator of fatigue in disease: a narrative review

Fatigue is commonly reported in a variety of illnesses, and it has major impact on quality of life. Previously, it was thought that fatigue originates in the skeletal muscles, leading to cessation of activity....

Megan E. Roerink, Marieke E. van der Schaaf… in Journal of Neuroinflammation (2017)

Article

Bartonella quintana lipopolysaccharide (LPS): structure and characteristics of a potent TLR4 antagonist for in-vitro and in-vivo applications

The pattern recognition receptor TLR4 is well known as a crucial receptor during infection and inflammation. Several TLR4 antagonists have been reported to inhibit the function of TLR4. Both natural occurring ...

Gosia Malgorzata-Miller, Lena Heinbockel, Klaus Brandenburg… in Scientific Reports (2016)

Article

Cytokine inhibition in chronic fatigue syndrome patients: study protocol for a randomized controlled trial

Chronic fatigue syndrome (CFS) is a medically unexplained syndrome for which no somatic or pharmacological treatment has been proven effective. Dysfunction of the cytokine network has been suspected to play a ...

Megan E. Roerink, Hans Knoop, Sebastian J. H. Bredie, Michael Heijnen… in Trials (2015)

Article

Immune defence against Candida fungal infections