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within Michael Schramm Remove this filter Science, Humanities and Social Sciences, multidisciplinary Remove this filter Science, multidisciplinary Remove this filter

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  1. No Access

    Article

    Resolution, reconstitution and kinetics of the primary action of a hormone receptor

    The β-adrenergic receptor (R) and the GTP binding protein (G) with which the receptor interacts were obtained in separate soluble fractions. Their recombination produced a hormone responsive system. In the pre...

    Yoav Citri, Michael Schramm in Nature (1980)

  2. No Access

    Article

    Riboflavin kinase couples TNF receptor 1 to NADPH oxidase

    Riboflavin kinase has been identified as a novel interacting partner for the death domain of receptor-1 for tumour necrosis factor (TNF-R1). It is required to recruit to and functionally couple p22phox to TNF-R1....

    Benjamin Yazdanpanah, Katja Wiegmann, Vladimir Tchikov, Oleg Krut… in Nature (2009)

  3. Article

    Open Access

    Corticosteroids inhibit Mycobacterium tuberculosis-induced necrotic host cell death by abrogating mitochondrial membrane permeability transition

    Corticosteroids are host-directed drugs with proven beneficial effect on survival of tuberculosis (TB) patients, but their precise mechanisms of action in this disease remain largely unknown. Here we show that...

    Jessica Gräb, Isabelle Suárez, Edeltraud van Gumpel, Sandra Winter… in Nature Communications (2019)

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  4. Article

    Open Access

    The TSPO-NOX1 axis controls phagocyte-triggered pathological angiogenesis in the eye

    Aberrant immune responses including reactive phagocytes are implicated in the etiology of age-related macular degeneration (AMD), a major cause of blindness in the elderly. The translocator protein (18 kDa) (T...

    Anne Wolf, Marc Herb, Michael Schramm, Thomas Langmann in Nature Communications (2020)

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