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Article
Generalizability of an acute kidney injury prediction model across health systems
Delays in the identification of acute kidney injury in hospitalized patients are a major barrier to the development of effective interventions for treatment. A recent study described a series of models that ou...
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Article
Open AccessLimited clinical utility for GWAS or polygenic risk score for postoperative acute kidney injury in non-cardiac surgery in European-ancestry patients
Prior studies support a genetic basis for postoperative acute kidney injury (AKI). We conducted a genome-wide association study (GWAS), assessed the clinical utility of a polygenic risk score (PRS), and estima...
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Article
Open AccessRegional citrate anticoagulation “non-shock” protocol with pre-calculated flow settings for patients with at least 6 L/hour liver citrate clearance
Regional citrate anticoagulation (RCA) for the prevention of clotting of the extracorporeal blood circuit during continuous kidney replacement therapy (CKRT) has been employed in limited fashion because of the...
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Article
Open AccessSevere secondary hyperkalemia and arrhythmia from drug interactions between calcium‐channel blocker and voriconazole: a case presentation
Patients with kidney disease may have concurrent hypertension and infection. Dihydropyridine calcium-channel blockers (CCB) are the most popular class of antihypertensive drugs used in clinical settings and ca...
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Article
Open AccessPredictors of kidney function recovery among incident ESRD patients
ESRD is considered an irreversible loss of renal function, yet some patients will recover kidney function sufficiently to come off dialysis. Potentially modifiable predictors of kidney recovery, such as dialys...
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Article
Open AccessExploring reasons for state-level variation in incidence of dialysis-requiring acute kidney injury (AKI-D) in the United States
There is considerable state-level variation in the incidence of dialysis-requiring acute kidney injury (AKI-D). However, little is known about reasons for this geographic variation.
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Article
Open AccessIdentification and validation of biomarkers of persistent acute kidney injury: the RUBY study
The aim of the RUBY study was to evaluate novel candidate biomarkers to enable prediction of persistence of renal dysfunction as well as further understand potential mechanisms of kidney tissue damage and repa...
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Article
Open AccessCram**, crashing, cannulating, and clotting: a qualitative study of patients’ definitions of a “bad run” on hemodialysis
Hemodialysis sessions frequently become unstable from complications such as intradialytic hypotension and untoward symptoms. Previous patient safety initiatives promote prevention of treatment complications; y...
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Chapter
Hyperkalemia
Hyperkalemia is a potentially life-threatening condition that occurs commonly among the critically ill, most commonly in the setting of acute or chronic renal failure. Hyperkalemia can develop from a variety o...
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Article
Open AccessThe relation between dialysis-requiring acute kidney injury and recovery from end-stage renal disease: a national study
Approximately 4–6% of incident end stage renal disease (ESRD) patients in the U.S. recover enough kidney function to discontinue dialysis but there is considerable geographic variation. We undertook this study...
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Article
Open AccessEffect of hyperchloremia on acute kidney injury in critically ill septic patients: a retrospective cohort study
Hyperchloremia is common in critically ill septic patients. The impact of hyperchloremia on the incidence of acute kidney injury (AKI) is not well studied. We investigated the association between hyperchloremi...
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Article
Open AccessCRRTnet: a prospective, multi-national, observational study of continuous renal replacement therapy practices
Continuous renal replacement therapy (CRRT) is the recommended modality of dialysis for critically ill patients with hemodynamic instability. Yet there remains significant variability in how CRRT is prescribed...
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Article
Open AccessContinuous quality improvement in nephrology: a systematic review
Continuous quality improvement (CQI) has been successfully applied in business and engineering for over 60 years. While using CQI techniques within nephrology has received increased attention, little is known ...
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Article
Validation of the KDIGO acute kidney injury criteria in a pediatric critical care population
Acute kidney injury (AKI) occurs commonly in critically ill children and has been associated with increased mortality of up to 50 %. The Kidney Disease: Improving Global Outcomes (KDIGO) AKI working group has ...
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Article
Implications of different fluid overload definitions in pediatric stem cell transplant patients requiring continuous renal replacement therapy
In critically ill pediatric patients, fluid overload (FO) >10% has been identified as a threshold for possible interventions, including initiation of continuous renal replacement therapy (CRRT). However, multi...
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Article
Weight-based determination of fluid overload status and mortality in pediatric intensive care unit patients requiring continuous renal replacement therapy
In pediatric intensive care unit (PICU) patients, fluid overload (FO) at initiation of continuous renal replacement therapy (CRRT) has been reported to be an independent risk factor for mortality. Previous stu...
