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  1. No Access

    Article

    Novel pyrrolidine-aminophenyl-1,4-naphthoquinones: structure-related mechanisms of leukemia cell death

    Novel derivatives of aminophenyl-1,4-naphthoquinones, in which a pyrrolidine group was added to the naphthoquinone ring, were synthesized and investigated for the mechanisms of leukemic cell killing. The novel...

    Maher Hallak, Michael Danilenko, Thida Win… in Molecular and Cellular Biochemistry (2023)

  2. No Access

    Chapter

    The Role of Tomato Lycopene in Cancer Prevention

    The role of the tomato carotenoid lycopene in cancer prevention has gained considerable interest in recent years. Most studies reported an inverse association between tomato intake or blood lycopene level and ...

    Joseph Levy, Shlomo Walfisch, Andrea Atzmon… in Vegetables, Whole Grains, and Their Deriva… (2011)

  3. No Access

    Article

    Lycopene and other carotenoids inhibit estrogenic activity of 17β-estradiol and genistein in cancer cells

    Epidemiological evidence suggests that carotenoids prevent several types of cancer, including mammary and endometrial cancers. On the other hand, such studies have also shown that estrogens are the most import...

    Keren Hirsch, Andrea Atzmon, Michael Danilenko… in Breast Cancer Research and Treatment (2007)

  4. No Access

    Article

    Lycopene inhibition of IGF-induced cancer cell growth depends on the level of cyclin D1

    Insulin-like growth factors (IGFs) play an important role in normal and cancerous cell proliferation. Moreover, in recent studies IGF-I has been implicated as a major cancer risk factor. The tomato carotenoid ...

    Amit Nahum, Lior Zeller, Michael Danilenko… in European Journal of Nutrition (2006)

  5. No Access

    Article

    Lycopene inhibition of cell cycle progression in breast and endometrial cancer cells is associated with reduction in cyclin D levels and retention of p27Kip1 in the cyclin E–cdk2 complexes

    Numerous studies have demonstrated the anticancer activity of the tomato carotenoid, lycopene. However, the molecular mechanism of this action remains unknown. Lycopene inhibition of human breast and endometri...

    Amit Nahum, Keren Hirsch, Michael Danilenko, Colin KW Watts, Owen WJ Prall… in Oncogene (2001)

  6. No Access

    Chapter and Conference Paper

    The Tomato Carotenoid Lycopene and Cancer

    The results of many epidemiological studies clearly indicate that there is inverse correlation between the consumption of fruits and vegetables and the incidence of various degenerative diseases such as cancer...

    Joseph Levy, Michael Danilenko, Yoav Sharoni in Food Factors for Cancer Prevention (1997)