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  1. No Access

    Article

    CRISPR germline engineering—the community speaks

    Nature Biotechnology asks selected members of the international community to comment on the ethical issues raised by the prospect of CRISPR-Cas9 engineering of the human germline.

    Katrine S Bosley, Michael Botchan, Annelien L Bredenoord… in Nature Biotechnology (2015)

  2. No Access

    Article

    Nucleotide-dependent conformational changes in the DnaA-like core of the origin recognition complex

    Structural details of initiator proteins for DNA replication have provided clues to the molecular events in this process. EM reconstructions of the Drosophila melanogaster origin recognition complex (ORC) reveal ...

    Megan G Clarey, Jan P Erzberger, Patricia Grob… in Nature Structural & Molecular Biology (2006)