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Article
CRISPR germline engineering—the community speaks
Nature Biotechnology asks selected members of the international community to comment on the ethical issues raised by the prospect of CRISPR-Cas9 engineering of the human germline.
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Article
A switch for S phase
DNA replication is a necessary prelude to the division of a eukaryotic cell. Initiation of this process requires a complex script, involving many proteins: details of one of the main acts now emerge.
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Article
Nucleotide-dependent conformational changes in the DnaA-like core of the origin recognition complex
Structural details of initiator proteins for DNA replication have provided clues to the molecular events in this process. EM reconstructions of the Drosophila melanogaster origin recognition complex (ORC) reveal ...
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Article
Expression of enhanced levels of small RNA polymerase III transcripts encoded by the B2 repeats in simian virus 40-transformed mouse cells
Although specific viral genes are known which are sufficient to transform certain types of cells, viral transformation has been shown to he accompanied by a change in the level of expression of cellular genes....
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Article
Inhibition of SV40 replication in simian cells by specific pBR322 DNA sequences
SV40 DNA replication requires interactions between proteins provided by the host cell, the virus-coded A protein and a viral sequence of ∼80 base pairs (bp), which serves as an origin of DNA replication1,2. The a...
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Article
Ends of bacteriophage Mu DNA
THE temperate bacteriophage Mu does not prefer a specific attachment site on the chromosome of Escherichia coli and can apparently engineer the insertion of its DNA irrespective of the host sequences encountered1
