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Article
Revisiting current National Comprehensive Cancer Network (NCCN) high-risk prostate cancer stratification: a National Cancer Database analysis
High-risk prostate cancer includes heterogenous populations with variable outcomes. This study aimed to compare the prognostic ability of individual high-risk factors, as defined by National Comprehensive Canc...
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Article
Prospective comparison of restriction spectrum imaging and non-invasive biomarkers to predict upgrading on active surveillance prostate biopsy
Protocol-based active surveillance (AS) biopsies have led to poor compliance. To move to risk-based protocols, more accurate imaging biomarkers are needed to predict upgrading on AS prostate biopsy. We compare...
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Article
Open AccessHigh expression of Trop2 is associated with aggressive localized prostate cancer and is a candidate urinary biomarker
Distinguishing indolent from clinically significant localized prostate cancer is a major clinical challenge and influences clinical decision-making between treatment and active surveillance. The development of...
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Article
Open AccessPhagocytosis-initiated tumor hybrid cells acquire a c-Myc-mediated quasi-polarization state for immunoevasion and distant dissemination
While macrophage phagocytosis is an immune defense mechanism against invading cellular organisms, cancer cells expressing the CD47 ligand send forward signals to repel this engulfment. Here we report that the ...
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Diagnosis and Clinical Staging
Prostate cancer rarely presents with symptoms. The discovery of Prostate-Specific Antigen (PSA) and its utility in screening of prostate cancer led to controversies regarding over-diagnosis versus mortality be...
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Article
Open AccessPredictors of participants’ retention—socioeconomic factors or nonadherence: insights from a urological clinical prospective study
To investigate various patient-level variables, specifically socioeconomic status, as risk factors for withdrawal in a recently completed clinical study. We specifically investigated a non-interventional prosp...
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Article
Open AccessEffects of yoga in men with prostate cancer on quality of life and immune response: a pilot randomized controlled trial
Diagnosis and treatment of prostate cancer is associated with anxiety, fear, and depression in up to one-third of men. Yoga improves health-related quality of life (QoL) in patients with several types of cance...
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Article
Open AccessAccommodating heterogeneous missing data patterns for prostate cancer risk prediction
We compared six commonly used logistic regression methods for accommodating missing risk factor data from multiple heterogeneous cohorts, in which some cohorts do not collect some risk factors at all, and deve...
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Article
Survival after minimally invasive vs. open radical nephrectomy for stage I and II renal cell carcinoma
A recently reported phase III randomized trial comparing open and minimally invasive hysterectomy showed significantly higher rates of local recurrence after minimally invasive surgery (MIS) for cervical cance...
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Article
Open AccessComparison of rectal swab, glove tip, and participant-collected stool techniques for gut microbiome sampling
Studies of the gut microbiome are becoming increasingly important. Such studies require stool collections that can be processed or frozen in a timely manner so as not to alter the microbial content. Due to the...
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Article
Systematic Review of Current Ultrasound Use in Education and Simulation in the Field of Urology
We investigate articles in the literature published in the last 5 years (2014–2019) regarding ultrasound education in the specialty of urology.
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Article
Open AccessAttenuation of NAD[P]H:quinone oxidoreductase 1 aggravates prostate cancer and tumor cell plasticity through enhanced TGFβ signaling
NAD[P]H:quinone oxidoreductase 1 (NQO1) regulates cell fate decisions in response to stress. Oxidative stress supports cancer maintenance and progression. Previously we showed that knockdown of NQO1 (NQO1low) pro...
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Article
Open AccessMulti-cohort modeling strategies for scalable globally accessible prostate cancer risk tools
Online clinical risk prediction tools built on data from multiple cohorts are increasingly being utilized for contemporary doctor-patient decision-making and validation. This report outlines a comprehensive da...
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Article
The Microbiome and Prostate Cancer Risk
There is an abundance of evidence that the human microbiome plays an important and nuanced role in controlling human metabolism, immunity, and cancer. Herein we aim to review the most current research looking ...
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Article
Higher baseline dietary fat and fatty acid intake is associated with increased risk of incident prostate cancer in the SABOR study
To study the association of nutrient intake measured by baseline food frequency questionnaire and risk of subsequent prostate cancer (PCa) in the SABOR (San Antonio Biomarkers of Risk) cohort study.
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Article
The effectiveness of targeted relative to empiric prophylaxis on infectious complications after transrectal ultrasound-guided prostate biopsy: a meta-analysis
Rectal culture screening for fluoroquinolone (FQ)-resistant Enterobacteriaceae before transrectal ultrasound guided prostate (TRUSPB) biopsy and targeted antibiotic prophylaxis (TAP) may decrease post-TRUSPB i...
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Article
Rational antibiotic sustainability for transrectal prostate biopsy prophylaxis
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Article
Prophylactic antibiotic for prostate biopsy: the carbapenem gamble
Sepsis is an infrequent but serious adverse risk of transrectal ultrasonography-guided prostate biopsy. A new study evaluated whether the use of single-dose ertapenem, a broad-spectrum antibiotic, resulted in ...
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Article
Validation of 3D volumetric-based renal function prediction calculator for nephron sparing surgery
To evaluate a recently published volume-based renal function prediction calculator intended to be used in small renal mass surgical counseling.
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Article
Restriction spectrum imaging improves MRI-based prostate cancer detection
To compare the diagnostic performance of restriction spectrum imaging (RSI), with that of conventional multi-parametric (MP) magnetic resonance imaging (MRI) for prostate cancer (PCa) detection in a blinded r...
