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Article
Stereospecific alkenylidene homologation of organoboronates by SNV reaction
Concerted nucleophilic substitution, known as SN2 reaction, is a fundamental organic transformation used in synthesis to introduce new functional groups and construct carbon–carbon and carbon–heteroatom bonds1. S
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Article
Global Well-posedness for the Fourth-order Defocusing Cubic Equation with Initial Data Lying in a Critical Sobolev Space
This paper is devoted to study the Cauchy problem of the fourth-order defocusing, cubic equation iut + Δ2u = − ∣u∣2u in critical Sobolev space. We first prove that the problem is local well-posed in the critical ...
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Article
Open AccessCorrection: Melatonin synergizes BRAF-targeting agent vemurafenib in melanoma treatment by inhibiting iNOS/hTERT signaling and cancer-stem cell traits
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Article
Open AccessTargeted inhibition of DHODH is synergistic with BCL2 blockade in HGBCL with concurrent MYC and BCL2 rearrangement
High-grade B-cell lymphoma (HGBCL), the subtype of non-Hodgkin lymphoma, to be relapsed or refractory in patients after initial therapy or salvage chemotherapy. Dual dysregulation of MYC and BCL2 is one of the...
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Article
Treatment of myelofibrosis with refractory anemia with luspatercept: a multicenter Chinese study
Myelofibrosis is a rare and often fatal hematological neoplasm, and the treatment of myelofibrosis-associated anemia remains suboptimal, with no improved therapies. Luspatercept was shown to display some effic...
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Article
Open AccessPreliminary study of cyclosporine A/Lifitegrast subconjunctival sustained-release drug membrane in the treatment of dry eyes
Dry eyes can cause discomfort. To treat dry eye disease, cyclosporine A (CsA) and Lifitegrast are two eye drugs approved by the U.S. Food and Drug Administration (FDA). However, frequent use of eye drops can b...
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Article
Open AccessSynergistic effect between biochar and sulfidized nano-sized zero-valent iron enhanced cadmium immobilization in a contaminated paddy soil
Biochar-based sulfidized nano-sized zero-valent iron (SNZVI/BC) can effectively immobilize cadmium (Cd) in contaminated paddy soils. However, the synergistic effects between biochar and SNZVI on Cd immobilizat...
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Article
Comparison of human leukocyte antigen in patients with paroxysmal nocturnal hemoglobinuria of different clone sizes
Glycosylphosphatidylinositol-anchored protein-deficient hematopoietic stem and progenitor cell development caused by PIGA mutations cannot fully explain the pathogenesis of paroxysmal nocturnal hemoglobinuria (PN...
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Article
Open AccessHigh-frame-rate contrast-enhanced ultrasound to differentiate between clear cell renal cell carcinoma and angiomyolipoma
To investigate the diagnostic efficacy of high-frame-rate contrast-enhanced ultrasound (H-CEUS) in differentiating between clear cell renal cell carcinoma (CCRCC) and angiomyolipoma (AML).
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Article
Open AccessFLI1 promotes IFN-γ-induced kynurenine production to impair anti-tumor immunity
Nasopharyngeal carcinoma (NPC)-mediated immunosuppression within the tumor microenvironment (TME) frequently culminates in the failure of otherwise promising immunotherapies. In this study, we identify tumor-i...
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Article
Stand structural diversity and edaphic properties regulate aboveground biomass of Abies fargesii var. faxoniana primary forest on the eastern Qinghai-Tibetan Plateau
Plant aboveground biomass reflects the resilience of ecosystem productivity to different environmental factors and plays an important role in biodiversity and ecosystem carbon cycles. Although many studies hav...
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Article
STK10 mutations block erythropoiesis in acquired pure red cell aplasia via impairing ribosome biogenesis
Acquired pure red cell aplasia (PRCA) is anemia associated with the absence of erythroblasts and is characterized by persistent and easy recurrence. However, the underlying mechanisms of acquired PRCA remain o...
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Article
Elevational Patterns and Drivers of Leaf Carbon, Nitrogen, and Phosphorus Stoichiometry in an Alpine-Gorge Region on the Eastern Qinghai-Tibetan Plateau
The study aimed to reveal the elevational patterns and drivers of leaf carbon (C), nitrogen (N), and phosphorus (P) concentrations and their stoichiometry at both the individual and community levels in the alp...
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Article
Sexual dimorphism in thermogenic regulators and metrnl expression in adipose tissue of offspring mice exposed to maternal and postnatal overnutrition
Current study investigated the impact of maternal and postnatal overnutrition on phenotype of adipose, in relation to offspring thermogenesis and sex. Female C57BL/6 J mice were fed with CHOW or high fat diet ...
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Article
Open AccessVDR and deubiquitination control neuronal oxidative stress and microglial inflammation in Parkinson’s disease
Close correlation between vitamin D (VitD) deficiency and Parkinson’s Disease (PD) risk, VitD as an adjuvant treatment promising to improve PD progression. However, VitD excessive intake could induce hypercalc...
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Article
Synthesis of alkenyl boronates through stereoselective vinylene homologation of organoboronates
Matteson homologation of organoboronates is an attractive approach for constructing aliphatic carbon chains via iterative insertion of carbenoids. However, the corresponding homologation that can introduce alk...
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Article
Open AccessImpact of hyperoxia on the gut during critical illnesses
Molecular oxygen is typically delivered to patients via oxygen inhalation or extracorporeal membrane oxygenation (ECMO), potentially resulting in systemic hyperoxia from liberal oxygen inhalation or localized ...
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Article
Open AccessAssociation between modifiable lifestyle factors and telomere length: a univariable and multivariable Mendelian randomization study
Telomere length has long been recognized as a valuable biomarker of aging and is inversely correlated with chronological age. Various lifestyle factors have been implicated in telomere shortening or preservati...
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Article
Dysphagia Pattern in Early to Moderate Parkinson’s Disease Caused by Abnormal Pharyngeal Kinematic Function
Airway invasion is common in patients with Parkinson’s disease (PD) and can cause serious complications. However, a PD-related dysphagic pattern has not been clearly elucidated. In this study, 53 patients with...
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Chapter and Conference Paper
Basketball Technical Feature Target Detection System Based on Artificial Intelligence
Basketball is a relatively popular sports event. Its movements are flexible. The ball changes are diverse, and it has strong ornamental value, so it is deeply loved by sports enthusiasts. In basketball, the le...
