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  1. Article

    Open Access

    MicroRNA-93-5p regulates odontogenic differentiation and dentin formation via KDM6B

    Epigenetic factors influence the odontogenic differentiation of dental pulp stem cells and play indispensable roles during tooth development. Some microRNAs can epigenetically regulate other epigenetic factors...

    Si Wu, **n Xu, Shiqi Gao, Sibei Huo, Mian Wan in Journal of Translational Medicine (2024)

  2. Article

    Open Access

    METTL3 enhances dentinogenesis differentiation of dental pulp stem cells via increasing GDF6 and STC1 mRNA stability

    The dentinogenesis differentiation of dental pulp stem cells (DPSCs) is controlled by the spatio-temporal expression of differentiation related genes. RNA N6-methyladenosine (m6A) methylation, one of the most abu...

    Yue Pan, Ying Liu, Dixin Cui, Sihan Yu, Yachuan Zhou, **n Zhou, Wei Du in BMC Oral Health (2023)

  3. No Access

    Article

    A large pool of actively cycling progenitors orchestrates self-renewal and injury repair of an ectodermal appendage

    The classical model of tissue renewal posits that small numbers of quiescent stem cells (SCs) give rise to proliferating transit-amplifying cells before terminal differentiation. However, many organs house poo...

    Amnon Sharir, Pauline Marangoni, Rapolas Zilionis, Mian Wan in Nature Cell Biology (2019)

  4. Article

    Open Access

    Disturbed bone remodelling activity varies in different stages of experimental, gradually progressive apical periodontitis in rats

    Bone remodelling keeps going through the lifespan of human by bone formation and bone resorption. In the craniofacial region, mandibles act as the main force for biting and chewing, and also become susceptible...

    Ruoshi Xu, Daimo Guo, Xuedong Zhou, Jianxun Sun in International Journal of Oral Science (2019)

  5. Article

    Open Access

    Spatial signalling mediated by the transforming growth factor-β signalling pathway during tooth formation

    Tooth development relies on sequential and reciprocal interactions between the epithelial and mesenchymal tissues, and it is continuously regulated by a variety of conserved and specific temporal-spatial signa...

    **n-Yu He, Ke Sun, Ruo-Shi Xu, Jia-Li Tan in International Journal of Oral Science (2016)

  6. Article

    Open Access

    BMP7 and EREG Contribute to the Inductive Potential of Dental Mesenchyme

    Odontogenesis is accomplished by reciprocal signaling between the epithelial and mesenchymal compartments. It is generally accepted that the inductive mesenchyme is capable of inducing the odontogenic commitme...

    Bo Gao, **n Zhou, Xuedong Zhou, Caixia Pi, Ruoshi Xu, Mian Wan in Scientific Reports (2015)

  7. Chapter and Conference Paper

    A Covert Channel Using Event Channel State on Xen Hypervisor

    Covert channel between virtual machines is one of serious threats to cloud computing, since it will break the isolation of guest OSs. Even if a lot of work has been done to resist covert channels, new covert c...

    Qingni Shen, Mian Wan, Zhuangzhuang Zhang in Information and Communications Security (2013)