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Open AccessClinical Implementation of Integrated Genomic Profiling in Patients with Advanced Cancers
DNA focused panel sequencing has been rapidly adopted to assess therapeutic targets in advanced/refractory cancer. Integrated Genomic Profiling (IGP) utilising DNA/RNA with tumour/normal comparisons in a Clini...
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Open AccessPhylogeography of Francisella tularensis subspecies holarctica from the country of Georgia
Francisella tularensis, the causative agent of tularemia, displays subspecies-specific differences in virulence, geographic distribution, and genetic diversity. F. tularensis subsp. holarctica is widely distribut...
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Playing for half the deck: the molecular biology of meiosis
Meiosis reduces the number of chromosomes carried by a diploid organism by half, partitioning precisely one haploid genome into each gamete. The basic events of meiosis reflect three meiosis-specific processes...