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Article
Open AccessPhytonanotherapeutic Applications of Plant Extract-Synthesized Silver Nanoparticles in Wound Healing—a Prospective Overview
Chronic wounds continue to pose severe threats to public health and the global economy. This is because the healing process is hindered by several factors, such as bacterial infections, comorbid conditions, ag...
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Article
Bioinformatics Prediction and Analysis of MicroRNAs and Their Targets as Biomarkers for Prostate Cancer: A Preliminary Study
Prostate cancer (PCa) is the second most common form of cancer in men around the world. Due to its heterogeneity, presentations range from aggressive lethal disease to indolent disease. There is a need to iden...
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Article
Open AccessMultifunctional Gold Nanoparticles for Improved Diagnostic and Therapeutic Applications: A Review
The medical properties of metals have been explored for centuries in traditional medicine for the treatment of infections and diseases and still practiced to date. Platinum-based drugs are the first class of m...
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Article
Open AccessImmunoinformatics design of a novel epitope-based vaccine candidate against dengue virus
Dengue poses a global health threat, which will persist without therapeutic intervention. Immunity induced by exposure to one serotype does not confer long-term protection against secondary infection with othe...
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Article
Open AccessNanotechnology advances towards development of targeted-treatment for obesity
Obesity through its association with type 2 diabetes (T2D), cancer and cardiovascular diseases (CVDs), poses a serious health threat, as these diseases contribute to high mortality rates. Pharmacotherapy alone...
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Article
Mycobacterium Tuberculosis and Interactions with the Host Immune System: Opportunities for Nanoparticle Based Immunotherapeutics and Vaccines
Tuberculosis (TB) caused by Mycobacterium tuberculosis remains a deadly infectious disease. The thin pipeline of new drugs for TB, the ineffectiveness in adults of the only vaccine available, i.e. the Bacillus Ca...
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Article
The cytotoxicity studies of water-soluble InP/ZnSe quantum dots
Biomedical applications require nanocrystals with a narrow emission spectra and low toxicity. One major challenge of using quantum dots (QDs) in biomedical studies has been to synthesize them in large quantiti...
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Article
Open AccessPleiocarpa pycnantha leaves and its triterpenes induce apoptotic cell death in Caco-2 cells in vitro
Recently, we reported that the crude fractions and pure triterpenes; ursolic acid (C1), 27-E and 27-Z p-coumaric esters of ursolic acid (C2, C3), together with a new triterpene 2,3-seco-taraxer-14-en-2,3-lactone ...
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Article
Targeted delivery using peptide-functionalised gold nanoparticles to white adipose tissues of obese rats
Obesity is a complex metabolic disease of excessive fat accumulation. It is a worldwide epidemic affecting billions of people. Current pharmacological treatment of obesity remains limited and ineffective due t...
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Article
De-regulation of the RBBP6 isoform 3/DWNN in human cancers
Retinoblastoma binding protein 6 (RBBP6) is a nuclear protein, previously implicated in the regulation of cell cycle and apoptosis. The human RBBP6 gene codes for three protein isoforms and isoform 3 consists of ...
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Article
In vitro evaluation of dichloro-bis(pyrazole)palladium(II) and dichloro-bis(pyrazole)platinum(II) complexes as anticancer agents
Cisplatin (cis-diamminedichloroplatinum) was first identified for its anti-bacterial activity, and was later also shown to be an efficient anticancer agent. However, the therapeutic use of this anticancer drug is...
