Skip to main content

14 Result(s)

within Menglong Li Remove this filter Biochemistry, general Remove this filter

and

  1. No Access

    Article

    Geraniol attenuates oxygen-glucose deprivation/reoxygenation-induced ROS-dependent apoptosis and permeability of human brain microvascular endothelial cells by activating the Nrf-2/HO-1 pathway

    Blood-brain barrier breakdown and ROS overproduction are important events during the progression of ischemic stroke aggravating brain damage. Geraniol, a natural monoterpenoid, possesses anti-apoptotic, cytopr...

    Ronggang Yang, Feng Yan, Jiangyi Shen… in Journal of Bioenergetics and Biomembranes (2024)

  2. No Access

    Article

    A consensual machine-learning-assisted QSAR model for effective bioactivity prediction of xanthine oxidase inhibitors using molecular fingerprints

    Xanthine oxidase inhibitors (XOIs) have been widely studied due to the promising potential as safe and effective therapeutics in hyperuricemia and gout. Currently, available XOI molecules have been developed f...

    Yanling Wu, Menglong Li, **ru Shen, Xuemei Pu, Yanzhi Guo in Molecular Diversity (2023)

  3. No Access

    Article

    Predicting HIV drug resistance using weighted machine learning method at target protein sequence-level

    Acquired immune deficiency syndrome (AIDS) is a fatal disease caused by human immunodeficiency virus (HIV). Although 23 different drugs have been available, the treatment of AIDS remains challenging because th...

    Qihang Cai, Rongao Yuan, Jian He, Menglong Li, Yanzhi Guo in Molecular Diversity (2021)

  4. No Access

    Article

    Combination use of protein–protein interaction network topological features improves the predictive scores of deleterious non-synonymous single-nucleotide polymorphisms

    Single-nucleotide polymorphisms (SNPs) are the most frequent form of genetic variations. Non-synonymous SNPs (nsSNPs) occurring in coding region result in single amino acid substitutions that associate with hu...

    Yiming Wu, Runyu **g, Lin Jiang, Yan** Jiang, Qifan Kuang, Ling Ye… in Amino Acids (2014)

  5. No Access

    Article

    Wavelet transform analysis of NMR structure ensembles to reveal internal fluctuations of enzymes

    Internal motions and flexibility are essential for biological functions in proteins. To assess the internal fluctuations and conformational flexibility of proteins, reliable computational methods are needed. I...

    Mei Hu, Yizhou Li, Gang Yang, Gongbing Li, Menglong Li, Zhining Wen in Amino Acids (2012)

  6. No Access

    Article

    Identification of RNA-binding sites in proteins by integrating various sequence information

    RNA–protein interactions play a pivotal role in various biological processes, such as mRNA processing, protein synthesis, assembly, and function of ribosome. In this work, we have introduced a computational me...

    Cui-cui Wang, Ya** Fang, Jiamin **ao, Menglong Li in Amino Acids (2011)

  7. No Access

    Article

    Prediction of Lipid-Binding Sites Based on Support Vector Machine and Position Specific Scoring Matrix

    Lipid–protein interactions play a vital role in various biological processes, which are involved in cellular functions and can affect the stability, folding and the function of peptides and proteins. In this s...

    Wenjia **ong, Yanzhi Guo, Menglong Li in The Protein Journal (2010)

  8. No Access

    Article

    Studying Peptides Biological Activities Based on Multidimensional Descriptors (E) Using Support Vector Regression

    A quantitative multidimensional amino acids descriptors E (E1–E5) has been introduced in bioactive peptides Quantitative Structure–Activity Relationship (QSAR) study. These descriptors correlate well with hydroph...

    Jiajian Yin, Yuanbo Diao, Zhining Wen… in International Journal of Peptide Research … (2010)

  9. No Access

    Article

    Using auto covariance method for functional discrimination of membrane proteins based on evolution information

    Membrane transporters are critical in living cells. Therefore, the discrimination of the types of membrane proteins based on their functions is of great importance both for hel** genome annotation and provid...

    Li Yang, Yizhou Li, Rongquan **ao, Yuhong Zeng, Jiamin **ao, Fuyuan Tan… in Amino Acids (2010)

  10. No Access

    Article

    Prediction of Beta-Turn in Protein Using E-SSpred and Support Vector Machine

    β-Turn is a secondary protein structure type that plays an important role in protein configuration and function. Here, we introduced an approach of β-turn prediction that used the support vector machine (SVM) ...

    Lirong Liu, Ya** Fang, Menglong Li, Cuicui Wang in The Protein Journal (2009)

  11. No Access

    Article

    An ensemble method based on a self-organizing map for near-infrared spectral calibration of complex beverage samples

    Based on a so-called ensemble strategy, an algorithm is proposed for near-infrared (NIR) spectral calibration of complex beverage samples. This algorithm is a combination of a novel training set/test set sampl...

    Chao Tan, **n Qin, Menglong Li in Analytical and Bioanalytical Chemistry (2008)

  12. No Access

    Article

    Study of the feasibility of distinguishing cigarettes of different brands using an Adaboost algorithm and near-infrared spectroscopy

    The feasibility of utilizing an Adaboost algorithm in conjuction with near-infrared (NIR) spectroscopy to automatically distinguish cigarettes of different brands was explored. Simple linear discriminant analy...

    Chao Tan, Menglong Li, **n Qin in Analytical and Bioanalytical Chemistry (2007)

  13. No Access

    Article

    Prediction of Mitochondrial Proteins Using Discrete Wavelet Transform

    A new method was proposed for prediction of mitochondrial proteins by the discrete wavelet transform, based on the sequence–scale similarity measurement. This sequence–scale similarity, revealing more informat...

    Lin Jiang, Menglong Li, Zhining Wen, Kelong Wang, Yuanbo Diao in The Protein Journal (2006)

  14. No Access

    Article

    Detection of oncoprotein platelet-derived growth factor using a fluorescent signaling complex of an aptamer and TOTO

    There have recently been advances in the application of aptamers, a new class of nucleic acids that bind specifically with target proteins, as protein recognition probes for biomedical study. The development o...

    Cuisong Zhou, Yaxin Jiang, Shuang Hou… in Analytical and Bioanalytical Chemistry (2006)