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  1. No Access

    Article

    Pre-encoded responsiveness to type I interferon in the peripheral immune system defines outcome of PD1 blockade therapy

    Type I interferons (IFN-Is) are central regulators of anti-tumor immunity and responses to immunotherapy, but they also drive the feedback inhibition underlying therapeutic resistance. In the present study, we...

    Giselle M. Boukhaled, Ramy Gadalla, Heidi J. Elsaesser… in Nature Immunology (2022)

  2. No Access

    Article

    Dynamic CD4+ T cell heterogeneity defines subset-specific suppression and PD-L1-blockade-driven functional restoration in chronic infection

    Inhibiting PD-1:PD-L1 signaling has transformed therapeutic immune restoration. CD4+ T cells sustain immunity in chronic infections and cancer, yet little is known about how PD-1 signaling modulates CD4+ helper T...

    Laura M. Snell, Wenxi Xu, Diala Abd-Rabbo, Giselle Boukhaled… in Nature Immunology (2021)