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  1. Article

    Open Access

    Acute ischemia induces spatially and transcriptionally distinct microglial subclusters

    Damage in the ischemic core and penumbra after stroke affects patient prognosis. Microglia immediately respond to ischemic insult and initiate immune inflammation, playing an important role in the cellular inj...

    Huiya Li, Pinyi Liu, Bing Zhang, Zengqiang Yuan, Mengdi Guo, **nxin Zou… in Genome Medicine (2023)

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  2. No Access

    Article

    Pre-encoded responsiveness to type I interferon in the peripheral immune system defines outcome of PD1 blockade therapy

    Type I interferons (IFN-Is) are central regulators of anti-tumor immunity and responses to immunotherapy, but they also drive the feedback inhibition underlying therapeutic resistance. In the present study, we...

    Giselle M. Boukhaled, Ramy Gadalla, Heidi J. Elsaesser… in Nature Immunology (2022)

  3. No Access

    Chapter and Conference Paper

    Dynamic Gas Control Strategy for Mode Switching in a Proton Exchange Membrane Unitized Regenerative Fuel Cell

    Proton exchange membrane unitized regenerative fuel cell (PEM-URFC) is a particular kind of fuel cell which combines fuel cell (FC) and water electrolyzer (WE) together. The mode switching from FC operating mo...

    Mengdi Guo, Zhonghao Zhang, Zhonghao Yu… in Renewable Energy Systems in Smart Grid (2022)

  4. No Access

    Chapter

    TLR Signaling in Brain Immunity

    Toll-like receptors (TLRs) comprise a group of transmembrane proteins with crucial roles in pathogen recognition, immune responses, and signal transduction. This family represented the first line of immune hom...

    Mengdi Guo, Yun Xu, Cun-** Zhang in Toll-like Receptors in Health and Disease (2022)

  5. No Access

    Article

    Dynamic CD4+ T cell heterogeneity defines subset-specific suppression and PD-L1-blockade-driven functional restoration in chronic infection

    Inhibiting PD-1:PD-L1 signaling has transformed therapeutic immune restoration. CD4+ T cells sustain immunity in chronic infections and cancer, yet little is known about how PD-1 signaling modulates CD4+ helper T...

    Laura M. Snell, Wenxi Xu, Diala Abd-Rabbo, Giselle Boukhaled… in Nature Immunology (2021)

  6. Article

    Open Access

    Age and regional disparity in HIV education among migrants in China: migrants population dynamic monitoring survey, 2014–2015

    A lack of education among migrants remains an important but overlooked issue that indirectly contributes to HIV transmission. It is necessary to know who has received HIV education and who has a lower probabil...

    Zheng Zhu, Mengdi Guo, Darina V. Petrovsky… in International Journal for Equity in Health (2019)

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  7. Article

    Open Access

    An interim report on the investigator-initiated phase 2 study of pembrolizumab immunological response evaluation (INSPIRE)

    Immune checkpoint inhibitors (ICIs) demonstrate unprecedented efficacy in multiple malignancies; however, the mechanisms of sensitivity and resistance are poorly understood and predictive biomarkers are scarce...

    Derek L. Clouthier, Scott C. Lien, S. Y. Cindy Yang… in Journal for ImmunoTherapy of Cancer (2019)

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