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Article
A novel FAK-degrading PROTAC molecule exhibited both anti-tumor activities and efficient MDR reversal effects
FAK (focal adhesion kinase) is widely involved in cancer growth and drug resistance development. Thus, FAK inhibition has emerged as an effective strategy for tumor treatment both as a monotherapy or in combin...
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Article
Open AccessReciprocal relationship between self-efficacy and achievement in mathematics among high school students
Self-efficacy or perceived ability refers to the confidence an individual has in their ability to successfully perform a specific task. Previous researchers have demonstrated the importance of self-efficacy be...
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Article
Publisher Correction: Ozone pollution mitigation strategy informed by long-term trends of atmospheric oxidation capacity
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Article
Framework for incorporating multi-level morphology of particles in DEM simulations: independent control of polydisperse distributions of roundness and roughness while preserving form distributions in granular materials
Particle shape in granular materials exhibits both polydisperse and multi-level characteristics, which are intrinsically linked to the mechanical behaviours of granular materials. This study develops a particl...
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Article
Toward Establishing a Low-cost UAV Coordinated Carbon Observation Network (LUCCN): First Integrated Campaign in China
In this study, we introduce our newly developed measurement-fed-perception self-adaption Low-cost UAV Coordinated Carbon Observation Network (LUCCN) prototype. The LUCCN primarily consists of two categories of...
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Article
Ozone pollution mitigation strategy informed by long-term trends of atmospheric oxidation capacity
Tropospheric ozone pollution is a critical air-quality concern in China. However, the most effective mitigation approach remains unclear, with prioritizing the reduction of volatile organic compounds or nitrog...
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Article
Synergistic relationship and interact driving factors of pollution and carbon reduction in the Yangtze River Delta urban agglomeration, China
The urban agglomeration is the most concentrated region of economy, population, and industry. It is also the key area of carbon emissions (CE) and air pollution management. CE and air pollution have the possib...
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Article
Open AccessIdentification of genetic loci jointly influencing COVID-19 and coronary heart diseases
Comorbidities of coronavirus disease 2019 (COVID-19)/coronary heart disease (CHD) pose great threats to disease outcomes, yet little is known about their shared pathology. The study aimed to examine whether co...
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Article
Weakening behavior of waterproof performance in joints of shield tunnels under adjacent constructions
Groundwater leakage in shield tunnels poses a threat to the safety and durability of tunnel structures. Disturbance of adjacent constructions during the operation of shield tunnels frequently occurs in China, ...
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Article
Ecological Effects of Predator Harvesting and Environmental Noises on Oceanic Coral Reefs
Coral reefs provide refuge for prey and are important for the preservation of an oceanic ecosystem. However, they have been experiencing severe destruction by environmental changes and human activities. In thi...
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Article
Micro-electrochemical DO sensor with ultra-micropore matrix fabricated with femtosecond laser processing successfully applied in on-line DO monitoring for yeast culture
Accurate monitoring of dissolved oxygen (DO) is vital for aerobic fermentation process control. This work presents an autoclavable Micro-Dissolved oxygen Sensor (MDS) that can monitor real time DO. The propose...
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Article
Open AccessAssessing the mechanism of citywide test-trace-isolate Zero-COVID policy and exit strategy of COVID-19 pandemic
Countries that aimed for eliminating the cases of COVID-19 with test-trace-isolate policy are found to have lower infections, deaths, and better economic performance, compared with those that opted for other m...
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Article
Open AccessA quasi-monolithic phase-field description for mixed-mode fracture using predictor–corrector mesh adaptivity
In this work, we develop a mixed-mode phase-field fracture model employing a parallel-adaptive quasi-monolithic framework. In nature, failure of rocks and rock-like materials is usually accompanied by the prop...
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Article
Hydrothermal carbon modified Cu–Fe oxide with enhanced Fe(II)/Fe(III) cycle to activate peroxydisulfate for phenol removal
Phenol is a typical organic pollutant in wastewater, which will cause considerable damage and threat to the ecosystem and human health. In this work, hydrothermal carbon (HTC) modified copper-iron oxide (CFO) ...
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Article
Open AccessDevelopment and validation of reassigned CEA, CYFRA21-1 and NSE-based models for lung cancer diagnosis and prognosis prediction
The majority of lung cancer(LC) patients are diagnosed at advanced stage with a poor prognosis. However, there is still no ideal diagnostic and prognostic prediction model for lung cancer.
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Article
Open AccessExosomal lncRNA TUG1 from cancer-associated fibroblasts promotes liver cancer cell migration, invasion, and glycolysis by regulating the miR-524-5p/SIX1 axis
Increasing evidence suggests that taurine upregulated gene 1 (TUG1) is crucial for tumor progression; however, its role in hepatocellular carcinoma (HCC) and the underlying mechanisms are not well characterized.
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Article
The critical role of STAT3 in biogenesis of tumor-derived exosomes with potency of inducing cancer cachexia in vitro and in vivo
Tumor-derived exosomes are emerging mediators of cancer cachexia. Clarifying the regulation of exosome biogenesis and finding possible targets for cancer cachexia therapy are important and necessary. In the pr...
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Article
Modeling and Evaluation of the Joint Prevention and Control Mechanism for Curbing COVID-19 in Wuhan
The spread of COVID-19 in Wuhan was successfully curbed under the strategy of “Joint Prevention and Control Mechanism.” To understand how this measure stopped the epidemics in Wuhan, we establish a compartment...
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Chapter and Conference Paper
Study on Adaptive Adjustment of Variable Joint Stiffness for a Semi-active Hip Prosthesis
The moment and impedance of the hip antagonist muscle groups can change dynamically with movement, but existing passive hip prostheses are unable to achieve this function and limit the walking ability of hip a...
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Chapter and Conference Paper
TDCT: Target-Driven Concolic Testing Using Extended Units by Calculating Function Relevance
Concolic unit testing is able to perform comprehensive analysis with a small function of the program. However, due to the following disadvantages, it cannot be widely and effectively applied to test the whole ...
